Kłoszewska Iwona
I Klinika Psychiatryczna Katedry Psychiatrii AM w Łodzi.
Psychiatr Pol. 2002 Nov-Dec;36(6 Suppl):133-41.
Based on a literature review, the application of Acetylcholinesterase inhibitors, IAchE (donepezil, rivastigmine, galantanine) in the treatment of various illnesses which have cholinergic system disability and dementia in their course--(dementia with Lewy bodies, vascular dementia, Parkinson's disease, Multiple Sclerosis, Down Syndrome), delirium symptoms (e.g. Korsakoff psychosis), hyperkinesis, attention and memory disorders--is presented. Promising results in the treatment of late dyskinesias, in schizophrenia with impaired cognitive function, as well as in the additional treatment of various psychotic states are noted. It should be stressed that in Poland, the IAchE have been approved only in the treatment of slight to moderate dementia in the course of Alzheimer's disease.
基于文献综述，介绍了乙酰胆碱酯酶抑制剂（IAchE，多奈哌齐、卡巴拉汀、加兰他敏）在治疗各种病程中存在胆碱能系统功能障碍和痴呆的疾病（路易体痴呆、血管性痴呆、帕金森病、多发性硬化症、唐氏综合征）、谵妄症状（如柯萨科夫精神病）、运动亢进、注意力和记忆障碍方面的应用。还提到了在治疗迟发性运动障碍、认知功能受损的精神分裂症以及各种精神状态的辅助治疗方面取得的有前景的结果。应当强调的是，在波兰，IAchE仅被批准用于治疗阿尔茨海默病病程中的轻度至中度痴呆。
