Jorissen Robert N, Walker Francesca, Pouliot Normand, Garrett Thomas P J, Ward Colin W, Burgess Antony W
Ludwig Institute for Cancer Research, Parkville, Victoria, Australia.
Exp Cell Res. 2003 Mar 10;284(1):31-53. doi: 10.1016/s0014-4827(02)00098-8.
The epidermal growth factor (EGF) receptor (EGFR) is one of four homologous transmembrane proteins that mediate the actions of a family of growth factors including EGF, transforming growth factor-alpha, and the neuregulins. We review the structure and function of the EGFR, from ligand binding to the initiation of intracellular signalling pathways that lead to changes in the biochemical state of the cell. The recent crystal structures of different domains from several members of the EGFR family have challenged our concepts of these processes.
表皮生长因子（EGF）受体（EGFR）是四种同源跨膜蛋白之一，介导包括EGF、转化生长因子-α和神经调节蛋白在内的一类生长因子的作用。我们综述了EGFR的结构与功能，从配体结合到导致细胞生化状态改变的细胞内信号通路的启动。EGFR家族几个成员不同结构域的最新晶体结构对我们关于这些过程的概念提出了挑战。
