Zidi Y S H, Bouraoui S, Atallah K, Kchir N, Haouet S
Pathology Department, La Rabta Hospital, Tunis, Tunisia.
Gynecol Oncol. 2003 Mar;88(3):444-6. doi: 10.1016/s0090-8258(02)00105-1.
Primary squamous cell carcinoma of the endometrium is exceedingly rare. It has been described in association with pyometra but its etiology is still unclear.
The authors report the case of a 75-year-old woman who presented with pelvic pain and pyometra. No gross tumor was identified in the uterus; however, extensive epidermalization of the endometrial mucosa was noted. Microscopic findings were consistent with a primary in situ squamous carcinoma of the endometrium associated with extensive squamous metaplasia and areas of dysplasia. HPV antigen and DNA detection were negative in both the endometrial lesions and the cervix.
These results support the sequence of change with squamous metaplasia, progressing through dysplasia to carcinoma as a possible pathogenetic process. HPV's role, however, remains uncertain.
子宫内膜原发性鳞状细胞癌极为罕见。它曾被描述与积脓相关，但其病因仍不清楚。
作者报告了一名75岁女性患者，该患者出现盆腔疼痛和积脓。子宫内未发现肉眼可见的肿瘤；然而，注意到子宫内膜黏膜有广泛的表皮化生。显微镜检查结果与伴有广泛鳞状化生和发育异常区域的子宫内膜原发性原位鳞状细胞癌一致。子宫内膜病变和宫颈的人乳头瘤病毒（HPV）抗原及DNA检测均为阴性。
这些结果支持鳞状化生、经发育异常发展为癌这一变化顺序作为一种可能的发病机制。然而，HPV的作用仍不确定。
