Nwafor Paul A, Okwuasaba F K
Department of Pharmacology, College of Medical Sciences, University of Maiduguri, PMB 1069, Maiduguri, Nigeria.
J Ethnopharmacol. 2003 Feb;84(2-3):125-9. doi: 10.1016/s0378-8741(02)00213-1.
The effect of methanolic extract of Asparagus pubescens was investigated on chemical, thermal-induced pain as well as fresh egg albumin-induced inflammation and pentylenetetrazol (PTZ)-induced convulsion in rodents. The extract dose-dependently (0.25-1.5 g/kg) inhibited acetic acid-induced writhing, formalin-induced pain licking and hot plate-induced pain in mice. The extract significantly inhibited both the fresh egg albumin-induced inflammation in rats as well as PTZ-induced convulsion in mice. These inhibitions were statistically significant (P < 0.02-0.001). It increased the latencies of both clonic and tonic convulsions and delayed their mortalities. Its ability to reduce both neurogenic and non-neurogenic pains may be related to its active constituents such as tannins, saponins, steroid and flavonoids.
研究了天门冬甲醇提取物对啮齿动物化学性、热诱导性疼痛以及新鲜蛋清诱导的炎症和戊四氮（PTZ）诱导的惊厥的影响。该提取物以剂量依赖性方式（0.25 - 1.5 g/kg）抑制小鼠乙酸诱导的扭体反应、福尔马林诱导的舔舐疼痛和热板诱导的疼痛。该提取物显著抑制大鼠新鲜蛋清诱导的炎症以及小鼠PTZ诱导的惊厥。这些抑制作用具有统计学意义（P < 0.02 - 0.001）。它增加了阵挛性和强直性惊厥的潜伏期，并延迟了动物死亡。其减轻神经源性和非神经源性疼痛的能力可能与其活性成分如单宁、皂苷、类固醇和黄酮类有关。
