College of Pharmacy, Chung-Ang University, Seoul, South Korea.
College of Pharmacy, Government College University Faisalabad, Faisalabad, Pakistan ; Institute of Pharmacology, Toxicology and Biochemical Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Bioimpacts. 2014;4(1):43-8. doi: 10.5681/bi.2014.013. Epub 2014 Apr 10.
In many pathological conditions, pain, inflammation and fever are interdependent to each other. Due to the use of synthetic drugs, many unwanted effects usually appear. Various studies have been conducted on Caesalpinia decapetala (C. decapetala) to evaluate its effects in the treatment of various diseases but no sufficient scientific literature is available online to prove its analgesic, anti-inflammatory and anti-pyretic activities.
The analgesic, anti-inflammatory and anti-pyretic activities of 70% aqueous methanolic and n-hexane extracts of C. decapetala was evaluated using Swiss albino mice (20-30 g).
The results showed that aqueous methanolic extract of C. decapetala at the dose of 100 mg/kg exhibited significant (p< 0.05) activities in various pain models including acetic acid-induced writhing (18.4 ± 0.53), formalin-induced licking (275 ± 4.18) and hot plate method (2.3 ± 0.0328); whereas, n-hexane extract showed its effects in acetic acid-induced writhing (20 ± 0.31), formalin-induced licking (293 ± 1.20) and hot plate method (2.224 ± 0.029) compared to the effects observed in control group animals. Similarly, the aqueous methanolic extract of C. decapetala after 2 h of treatment exhibited more significant anti-inflammatory (0.66 ± 0.06) and anti-pyretic (38.81 ± 0.05) activities compared to the control group animals.
From the findings of our present study, we concluded that the aqueous methanolic extract of C. decapetala has stronger analgesic, anti-inflammatory and anti-pyretic effects than its n-hexane extract. Further studies are required to investigate the active constituents of C. decapetala that exhibit analgesic, anti-inflammatory and anti-pyretic activities.
在许多病理情况下，疼痛、炎症和发热是相互依存的。由于合成药物的使用，通常会出现许多不良反应。已经对金雀花（Caesalpinia decapetala，C. decapetala）进行了各种研究，以评估其在治疗各种疾病中的作用，但网上没有足够的科学文献证明其具有镇痛、抗炎和退热作用。
使用瑞士白化小鼠（20-30 克）评估金雀花 70%甲醇和正己烷提取物的镇痛、抗炎和退热活性。
结果表明，金雀花甲醇提取物在 100 mg/kg 剂量下在各种疼痛模型中表现出显著（p<0.05）的活性，包括乙酸诱导的扭体（18.4 ± 0.53）、福尔马林诱导的舔舐（275 ± 4.18）和热板法（2.3 ± 0.0328）；而正己烷提取物在乙酸诱导的扭体（20 ± 0.31）、福尔马林诱导的舔舐（293 ± 1.20）和热板法（2.224 ± 0.029）中表现出作用，与对照组动物的作用相比。同样，金雀花甲醇提取物在治疗 2 小时后表现出更强的抗炎（0.66 ± 0.06）和退热（38.81 ± 0.05）作用。
根据我们目前的研究结果，我们得出结论，金雀花甲醇提取物具有比其正己烷提取物更强的镇痛、抗炎和退热作用。需要进一步研究来调查具有镇痛、抗炎和退热作用的金雀花的活性成分。
