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基于软膏的[两种乳酸菌名称未完整给出]组合可加速烧伤创面愈合。

Ointment-Based Combination of L. and L. Accelerate Burn Wound Healing.

作者信息

Mssillou Ibrahim, Agour Abdelkrim, Slighoua Meryem, Chebaibi Mohamed, Amrati Fatima Ez-Zahra, Alshawwa Samar Zuhair, Kamaly Omkulthom Al, El Moussaoui Abdelfattah, Lyoussi Badiaa, Derwich Elhoussine

机构信息

Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health and Quality of Life (SNAMOPEQ), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30050, Morocco.

Laboratory of Biotechnology, Health, Agrofood and Environment (LBEAS), Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco.

出版信息

Pharmaceuticals (Basel). 2022 Feb 25;15(3):289. doi: 10.3390/ph15030289.

DOI:10.3390/ph15030289
PMID:35337087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8954364/
Abstract

Burns constitute a major challenge in medical science, and plants can be part of the solution. L. (Asteraceae) and L. (Lamiaceae) are widely used in Moroccan traditional medicine to treat several diseases and possess high potency to cure wounds. This study aimed to investigate in vivo the analgesic, anti-inflammatory, and burn-healing effects of both plants and their mixture. The hydro-ethanolic extract of both plants was analyzed using high-performance liquid chromatography with diode-array detection (HPLC-DAD). Burns were conducted on dorsal part of rats, and the wound healing process was evaluated during 21 days. Gallic acid, caffeic acid, ferulic acid, and quercetin were identified in extract. The analysis recorded the presence of caffeic acid, rosmarinic acid, rutin, and quercetin in . The group treated with the mixture showed the lowest abdominal contractions (30.4 ± 7.52) with the highest percentage of inhibition (69.12 ± 7.04%). The inhibition of paw inflammation for was 47.65%, followed by (33.86%) and the mixture (30.41%). The mixture showed the highest wound contraction at day 7 (33.16 ± 14.33%) and day 14 (87.54 ± 3.98%). showed the highest wound contraction on the 21st day (99.28 ± 0.44%). In conclusion, both plants and their combination showed promising results for burn healing.

摘要

烧伤是医学领域的一项重大挑战，而植物可能是解决问题的一部分。菊科的[植物名称1]和唇形科的[植物名称2]在摩洛哥传统医学中被广泛用于治疗多种疾病，并且具有很强的伤口愈合能力。本研究旨在对这两种植物及其混合物的镇痛、抗炎和烧伤愈合效果进行体内研究。采用二极管阵列检测高效液相色谱法（HPLC-DAD）对这两种植物的水乙醇提取物进行分析。在大鼠背部进行烧伤实验，并在21天内评估伤口愈合过程。在[植物名称1]提取物中鉴定出了没食子酸、咖啡酸、阿魏酸和槲皮素。分析记录了[植物名称2]中存在咖啡酸、迷迭香酸、芦丁和槲皮素。用混合物处理的组腹部收缩次数最少（30.4±7.52），抑制率最高（69.12±7.04%）。[植物名称1]对爪部炎症的抑制率为47.65%，其次是[植物名称2]（33.86%）和混合物（30.41%）。混合物在第7天（33.16±14.33%）和第14天（87.54±3.98%）显示出最高伤口收缩率。[植物名称1]在第21天显示出最高伤口收缩率（99.28±0.44%）。总之，这两种植物及其组合在烧伤愈合方面均显示出有前景的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/5ba7b881b02b/pharmaceuticals-15-00289-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/e4127139ec7c/pharmaceuticals-15-00289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/eac4d4d1c727/pharmaceuticals-15-00289-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/712661dd9e4d/pharmaceuticals-15-00289-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/9d1d9ca3682a/pharmaceuticals-15-00289-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/56ef1764efd4/pharmaceuticals-15-00289-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/5ba7b881b02b/pharmaceuticals-15-00289-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/e4127139ec7c/pharmaceuticals-15-00289-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/eac4d4d1c727/pharmaceuticals-15-00289-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/712661dd9e4d/pharmaceuticals-15-00289-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/9d1d9ca3682a/pharmaceuticals-15-00289-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/56ef1764efd4/pharmaceuticals-15-00289-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3442/8954364/5ba7b881b02b/pharmaceuticals-15-00289-g006.jpg

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