Chowdhury S, Kumar R, Ganguly N K, Kumar L, Walia B N S
Community Medicine Department, PGIMER, Chandigarh 160012.
Indian J Med Sci. 2002 Jun;56(6):259-64.
In a double blind design, 1520 children aged < 10 years were individually randomised in vitamin A and placebo group in slums of Chandigarh. Children > 12, 6-12 and < 6 months of age received 200,000, 100,000, 500,000 I.U. of vitamin A respectively every 4 to 6 months during 15 months trial period. The prevalence of vitamin A deficiency was significantly reduced in vitamin A compared to placebo group during the follow-up period. In vitamin A group, incidence of diarrhoea and measles was significantly reduced but incidence of acute respiratory infections was not significantly different compared to control group. Risk of death was also significantly less in vitamin A group. Therefore, promotion of vitamin A rich diet or supplementation with synthetic vitamin A at 4-6 month interval should be a priority in populations where risk of vitamin A deficiency is high.
在一项双盲设计中，1520名10岁以下儿童在昌迪加尔的贫民窟被分别随机分配到维生素A组和安慰剂组。12岁以上、6至12岁以及6个月以下的儿童在15个月的试验期内每4至6个月分别接受20万、10万、50万国际单位的维生素A。在随访期间，与安慰剂组相比，维生素A组维生素A缺乏症的患病率显著降低。在维生素A组中，腹泻和麻疹的发病率显著降低，但与对照组相比，急性呼吸道感染的发病率没有显著差异。维生素A组的死亡风险也显著降低。因此，在维生素A缺乏风险较高的人群中，推广富含维生素A的饮食或每4至6个月补充合成维生素A应成为优先事项。
