Zhou Jing-Jun, Zhu Yun-Long, Pei Jian-Ming, Gao Zhan, Zhu Miao-Zhang
Department of Physiology, Fourth Military Medical University, Xi'an 710032.
Sheng Li Ke Xue Jin Zhan. 2002 Oct;33(4):299-304.
Diverse physiological stresses (e.g., heat shock, ischemia and hemodynamics) produce multiple changes in a cell that affect metabolic processes and cellular structures. In response, stress proteins are synthesized, and are thought to mediate cytoprotection through biological function as molecular chaperones. Accumulated evidence indicates that HSP70, HSP90, HSP47, HSP32 and HSP27 play an important role during cardiac ischemia, ischemia preconditioning, cardiac hypertrophy and vascular wall injury.
多种生理应激（如热休克、缺血和血流动力学）会使细胞产生多种变化，影响代谢过程和细胞结构。作为响应，应激蛋白被合成，并被认为通过作为分子伴侣的生物学功能介导细胞保护作用。越来越多的证据表明，热休克蛋白70（HSP70）、热休克蛋白90（HSP90）、热休克蛋白47（HSP47）、热休克蛋白32（HSP32）和热休克蛋白27（HSP27）在心脏缺血、缺血预处理、心肌肥大和血管壁损伤过程中发挥重要作用。
