Lacoste-Collin Laetitia, Roux Franck-Emmanuel, Gomez-Brouchet Anne, Despeyroux Marie-Line, Uro-Coste Emmanuelle, Coindre Jean-Michel, Delisle Marie-Bernadette
Department of Pathology, CHU Rangueil, Toulouse, France.
J Neurosurg. 2003 Mar;98(2 Suppl):218-21. doi: 10.3171/spi.2003.98.2.0218.
The authors report on a case of spinal inflammatory myofibroblastic tumor (IMT) in a 22-year-oldwoman. Neuroradiological features of this intradural extramedullary mass were suggestive of a meningioma or neurinoma. The lesion was easily resected following a T-9 laminectomy. Light microscopy showed a proliferation of spindle cells with prominent nucleoli on a fibrous or edematous background with infiltration of numerous lymphocytes and plasma cells. Some spindle cells immunostained positively for ALK1. This led to the diagnosis of IMT. The patient's postoperative course was complicated by a multifocal local recurrence requiring a second surgery, which was followed by radio- and chemotherapy. The occurrence of IMT in the spinal cord has rarely been reported. In this case, ALK overexpression was associated with early multifocal recurrence. This has been recently reported in this tumor typein other locations.
作者报告了一例22岁女性的脊髓炎性肌纤维母细胞瘤（IMT）。该硬膜内髓外肿块的神经放射学特征提示为脑膜瘤或神经鞘瘤。经T-9椎板切除术后，该病变易于切除。光镜检查显示在纤维性或水肿性背景上有梭形细胞增殖，核仁明显，并有大量淋巴细胞和浆细胞浸润。一些梭形细胞ALK1免疫染色呈阳性。这导致了IMT的诊断。患者术后病程因多灶性局部复发而复杂化，需要进行二次手术，随后进行放疗和化疗。脊髓IMT的发生鲜有报道。在本病例中，ALK过表达与早期多灶性复发相关。最近在其他部位的这种肿瘤类型中也有相关报道。
