Department of Orthopedic Surgery, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, P.R. China.
Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, P.R. China.
BMC Musculoskelet Disord. 2020 Nov 12;21(1):746. doi: 10.1186/s12891-020-03759-4.
Plasma cell granuloma (PCG) is a rare non-neoplastic entity, with the precise etiology remaining unclear. Vertebra-affected spinal PCG has not been reported yet. This report presented a case with cross-segment spinal PCG in thoracolumbar region.
A 32-year-old male patient presented to the authors' hospital since his health check-up results showed osteolytic lesions in the thoracolumbar spine. He felt asymptomatic throughout the course. Radiological examination revealed destructive changes at T12 and L1 vertebrae. Whereas laboratory examination excluded malignant tumor. The results of routine incisional biopsy remained inconclusive, thereby necessitating complete excision of the lesions. Finally, the infiltration of plasma cells observed by pathological examination of the surgical specimen confirmed the diagnosis of PCG.
To the authors' knowledge, this was the first case of cross-segment spinal PCG with osteolytic property. The possibility of PCG should be considered for the diagnosis and differential diagnosis of an osteolytic lesion in the spine. Since the etiology of PCG is unknown, the disorder was confirmed based on excluded diagnosis. Surgical resection is recommended both for the definite diagnosis and treatment of spinal PCG.
浆细胞肉芽肿（PCG）是一种罕见的非肿瘤性实体，其确切病因仍不清楚。脊椎受累的 PCG 尚未见报道。本报告介绍了一例胸腰椎跨节段 PCG 病例。
一名 32 岁男性因健康检查结果显示胸腰椎溶骨性病变就诊于作者医院。他在整个病程中无症状。影像学检查显示 T12 和 L1 椎体有破坏性改变。实验室检查排除恶性肿瘤。常规切开活检结果仍不确定，因此需要对病变进行完全切除。最后，手术标本的病理检查观察到浆细胞浸润，确诊为 PCG。
据作者所知，这是首例具有溶骨性特征的跨节段脊椎 PCG。对于脊椎溶骨性病变的诊断和鉴别诊断，应考虑 PCG 的可能性。由于 PCG 的病因不明，该疾病是通过排除诊断来确诊的。手术切除是明确诊断和治疗脊椎 PCG 的推荐方法。
