已获许可的全病毒体和亚病毒体流感疫苗在“高危”人群中的抗原性。
Antigenicity of licensed whole virion and subvirion influenza vaccines in "high risk" persons.
作者信息
Kasel J A, Couch R B, Six H R, Knight V
出版信息
Proc Soc Exp Biol Med. 1976 Apr;151(4):742-7. doi: 10.3181/00379727-151-39298.
PMID:1265060
Abstract
The frequency and magnitude of serum antibody response to type A and B influenza virus induced by whole virion and subvirion vaccines were essentially comparable. Immunization was followed in vaccinated individuals by an antihemagglutinin antibody response to the common antigenic determinant shared by the type A H3N2 viruses. Relatively few individuals developed antibody to the type-specific determinant.
摘要
全病毒颗粒疫苗和亚病毒颗粒疫苗诱导产生的针对甲型和乙型流感病毒的血清抗体反应的频率和幅度基本相当。接种疫苗的个体随后会出现针对甲型H3N2病毒共有的抗原决定簇的抗血凝素抗体反应。相对较少的个体产生针对型特异性决定簇的抗体。
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