实验性马流感免疫刺激复合物疫苗的抗原性和免疫原性
Antigenicity and immunogenicity of experimental equine influenza ISCOM vaccines.
作者信息
Mumford J A, Jessett D, Dunleavy U, Wood J, Hannant D, Sundquist B, Cook R F
机构信息
Animal Health Trust, Lanwades Park, Kennett, Suffolk, UK.
出版信息
Vaccine. 1994 Jul;12(9):857-63. doi: 10.1016/0264-410x(94)90297-6.
A comparison of the antigenicity and immunogenicity of ISCOM vaccines prepared from equine influenza viruses H3N8 and H7N7 was made with inactivated whole-virus vaccines containing equivalent amounts of virus haemagglutinin. ISCOMs stimulated superior antibody responses in terms of both amount and duration. As with conventional whole-virus vaccines, the levels of antibody to virus haemagglutinin induced by ISCOMs correlated with protection.
对由马流感病毒H3N8和H7N7制备的免疫刺激复合物（ISCOM）疫苗与含有等量病毒血凝素的灭活全病毒疫苗的抗原性和免疫原性进行了比较。ISCOM在抗体量和持续时间方面均刺激产生了更强的抗体反应。与传统全病毒疫苗一样，ISCOM诱导产生的针对病毒血凝素的抗体水平与保护作用相关。
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