成人全病毒颗粒与亚单位流感疫苗免疫原性的比较。
Comparison of immunogenicity of a whole virion and a subunit influenza vaccine in adults.
作者信息
Ortbals D W, Liebhaber H
出版信息
J Clin Microbiol. 1978 Oct;8(4):431-4. doi: 10.1128/jcm.8.4.431-434.1978.
Abstract
The immunogenicity and reactogenicity of a whole virus (Merck Sharp & Dohme) and a subunit (Wyeth) influenza A/New Jersey/76 vaccine were compared in a group of 214 normal adult subjects. Both the seroconversion rate and the magnitutde of hemagglutination inhibition antibody response were significantly (P less than 0.01) lower in the recipients of the subunit vaccine, whereas there were no significant differences in local or systemic reactions between the two preparations. On the basis of these data, we question the previous Public Health Service recommendation that one dose of either preparation of the influenza A/New Jersey/76 vaccine is equally efficacious in individuals over 24 years of age.
摘要
在214名正常成年受试者中比较了全病毒（默克夏普&多贺美公司）和亚单位（惠氏公司）甲型流感/新泽西/76疫苗的免疫原性和反应原性。亚单位疫苗接种者的血清转化率和血凝抑制抗体反应幅度均显著降低（P<0.01），而两种制剂在局部或全身反应方面无显著差异。基于这些数据，我们对美国公共卫生服务局先前的建议提出质疑，该建议认为一剂甲型流感/新泽西/76疫苗的任何一种制剂对24岁以上个体的效力相同。
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本文引用的文献
1
2
Measles vaccination. V. The booster effect of purified hemagglutinin in children previously immunized with this product or formalin-killed vaccine.麻疹疫苗接种。五、纯化血凝素对先前接种过该产品或福尔马林灭活疫苗的儿童的加强免疫效果。
Acta Paediatr Scand. 1966 Jan;55(1):73-8. doi: 10.1111/j.1651-2227.1966.tb15210.x.
3
Purified influenza virus vaccine. A study of viral reactivity and antigenicity.纯化流感病毒疫苗。病毒反应性和抗原性研究。
JAMA. 1968 Dec 2;206(10):2277-82.
4
5
Killed subunit influenza vaccine in children.
Pediatrics. 1973 Sep;52(3):416-9.
6
The role of serum haemagglutination-inhibiting antibody in protection against challenge infection with influenza A2 and B viruses.血清血凝抑制抗体在预防甲型流感病毒2型和乙型流感病毒攻击感染中的作用。
J Hyg (Lond). 1972 Dec;70(4):767-77. doi: 10.1017/s0022172400022610.
7
Inactivated influenza vaccine efficacy: diminished antigenicity of split-product vaccines in mice.灭活流感疫苗的效力：裂解产物疫苗在小鼠体内的抗原性降低
Infect Immun. 1974 Dec;10(6):1329-36. doi: 10.1128/iai.10.6.1329-1336.1974.
8
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