成人全病毒颗粒与亚单位流感疫苗免疫原性的比较。
Comparison of immunogenicity of a whole virion and a subunit influenza vaccine in adults.
作者信息
Ortbals D W, Liebhaber H
出版信息
J Clin Microbiol. 1978 Oct;8(4):431-4. doi: 10.1128/jcm.8.4.431-434.1978.
Abstract
The immunogenicity and reactogenicity of a whole virus (Merck Sharp & Dohme) and a subunit (Wyeth) influenza A/New Jersey/76 vaccine were compared in a group of 214 normal adult subjects. Both the seroconversion rate and the magnitutde of hemagglutination inhibition antibody response were significantly (P less than 0.01) lower in the recipients of the subunit vaccine, whereas there were no significant differences in local or systemic reactions between the two preparations. On the basis of these data, we question the previous Public Health Service recommendation that one dose of either preparation of the influenza A/New Jersey/76 vaccine is equally efficacious in individuals over 24 years of age.
摘要
在214名正常成年受试者中比较了全病毒（默克夏普&多贺美公司）和亚单位（惠氏公司）甲型流感/新泽西/76疫苗的免疫原性和反应原性。亚单位疫苗接种者的血清转化率和血凝抑制抗体反应幅度均显著降低（P<0.01），而两种制剂在局部或全身反应方面无显著差异。基于这些数据，我们对美国公共卫生服务局先前的建议提出质疑，该建议认为一剂甲型流感/新泽西/76疫苗的任何一种制剂对24岁以上个体的效力相同。
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