Börner Nicole, Mühlberger Nikolai, Jelinek Tomas
Department of Infectious Diseases and Tropical Medicine, University of Munich, Munich, Germany.
J Travel Med. 2003 Mar-Apr;10(2):112-6. doi: 10.2310/7060.2003.31690.
Due to time constraints imposed by pending departure dates of travelers, the application of multiple vaccinations is commonly practiced in pretravel counseling. However, data regarding the tolerability of schedules with simultaneous vaccinations with different products are sparse.
In order to investigate effects of this practice, a prospective study was conducted with 1,183 healthy travelers who presented prior to their departure. Standardized questionnaires covering possible side effects were collected during and after vaccination.
Results showed an increase of the overall frequency of side effects with an increasing number of simultaneously applied vaccines. In travelers with two or more vaccinations, side effects occurred less frequently than previously published. In double vaccinations, side effects occurred in 36.7% of vaccinees, triple vaccinations in 40.3%, in more than three vaccinations in 50.0%. Subjective rating by the vaccinees showed an excellent tolerability of multiple vaccinations.
Multiple vaccines can be given at the same time with limited subjective side effects. These findings may increase the acceptability of vaccinations given in combination to travelers.
由于旅行者即将出发的日期所带来的时间限制，在旅行前咨询中通常会同时接种多种疫苗。然而，关于不同产品同时接种疫苗的方案耐受性的数据却很稀少。
为了研究这种做法的效果，对1183名出发前前来咨询的健康旅行者进行了一项前瞻性研究。在接种疫苗期间和之后收集了涵盖可能副作用的标准化问卷。
结果显示，随着同时接种疫苗数量的增加，副作用的总体发生率有所上升。在接种两种或更多疫苗的旅行者中，副作用的发生频率低于先前公布的数据。在双重接种中，36.7%的接种者出现副作用，三重接种为40.3%，超过三次接种为50.0%。接种者的主观评价显示多种疫苗具有良好的耐受性。
多种疫苗可以同时接种，主观副作用有限。这些发现可能会提高旅行者对联合接种疫苗的接受度。
