Moseley T A, Haudenschild D R, Rose L, Reddi A H
Department of Orthopaedic Surgery, Center for Tissue Regeneration and Repair, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.
Cytokine Growth Factor Rev. 2003 Apr;14(2):155-74. doi: 10.1016/s1359-6101(03)00002-9.
Interleukin-17 (IL-17) is a pro-inflammatory cytokine secreted by activated T-cells. Recently discovered related molecules are forming a family of cytokines, the IL-17 family. The prototype member of the family has been designated IL-17A. Due to recent advances in the human genome sequencing and proteomics five additional members have been identified and cloned: IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. The cognate receptors for the IL-17 family identified thus far are: IL-17R, IL-17RH1, IL-17RL (receptor like), IL-17RD and IL-17RE. However, the ligand specificities of many of these receptors have not been established. The IL-17 signaling system is operative in disparate tissues such as articular cartilage, bone, meniscus, brain, hematopoietic tissue, kidney, lung, skin and intestine. Thus, the evolving IL-17 family of ligands and receptors may play an important role in the homeostasis of tissues in health and disease beyond the immune system. This survey reviews the biological actions of IL-17 signaling in cancers, musculoskeletal tissues, the immune system and other tissues.
白细胞介素-17（IL-17）是一种由活化T细胞分泌的促炎细胞因子。最近发现的相关分子正在形成一个细胞因子家族，即IL-17家族。该家族的原型成员被命名为IL-17A。由于人类基因组测序和蛋白质组学的最新进展，又鉴定并克隆出了另外五个成员：IL-17B、IL-17C、IL-17D、IL-17E和IL-17F。迄今为止确定的IL-17家族的同源受体有：IL-17R、IL-17RH1、IL-17RL（类受体）、IL-17RD和IL-17RE。然而，这些受体中许多的配体特异性尚未确定。IL-17信号系统在不同组织中发挥作用，如关节软骨、骨骼、半月板、大脑、造血组织、肾脏、肺、皮肤和肠道。因此，不断演变的IL-17配体和受体家族可能在免疫系统之外的健康和疾病状态下的组织稳态中发挥重要作用。本综述回顾了IL-17信号在癌症、肌肉骨骼组织、免疫系统和其他组织中的生物学作用。
