Jugdutt Bodh I
Walter Mackenzie Health Sciences Center, Cardiology Division, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Heart Fail Rev. 2003 Jan;8(1):29-34. doi: 10.1023/a:1022190820131.
Nitric oxide (NO) plays a critical role in ischemic heart disease and ischemia-reperfusion. There is an increasing body of evidence to support the role of NO in myocardial and vascular protection in disease. The finding that NO might act as a trigger of late ischemic preconditioning (IPC) might lead to the development of novel anti-ischemic therapy. The role of NO signaling in the cardioprotective effects of ACE inhibitors and angiotensin II type 1 receptor(AT(1)) receptor antagonists is an active area of study.
一氧化氮（NO）在缺血性心脏病和缺血再灌注过程中发挥着关键作用。越来越多的证据支持NO在疾病的心肌和血管保护中的作用。NO可能作为晚期缺血预处理（IPC）触发因素的这一发现，可能会促成新型抗缺血疗法的开发。NO信号在血管紧张素转换酶抑制剂和1型血管紧张素II受体（AT(1)）拮抗剂的心脏保护作用中的角色，是一个活跃的研究领域。
