Li Ailing, Hogan Daniel J, Sanusi I Daniel, Smoller Bruce R
Department of Pathology, Louisiana State University Health Science Center, Shreveport, USA.
Am J Dermatopathol. 2003 Apr;25(2):113-6. doi: 10.1097/00000372-200304000-00004.
The relationship between granuloma annulare (GA) and malignant neoplasms is uncertain. Several case reports and clinical correlation studies have addressed this issue; however, no review articles have summarized those reported cases and statistically analyzed the association. Fourteen case reports and two correlation studies directly addressing the relationship of GA and malignant neoplasms were found from the Medline database from 1966-2001. A total of 16 cases from case reports were available with the mean age of 54. Most of the GA patients had an atypical clinical presentation. The time between the onset of GA and the discovery of the malignant neoplasms varied from 18 months before (median = 5 months) to 7 years after (median = 42 months). More than half of those cases were associated with lymphoma. No definite relationship was found between GA and malignant neoplasms. Older patients with skin lesions not clinically typical of GA but that histologically resemble classic GA, may be considered for investigation of underlying malignant lymphoma or other malignancies.
环状肉芽肿（GA）与恶性肿瘤之间的关系尚不确定。已有多篇病例报告及临床相关性研究探讨了这一问题；然而，尚无综述文章对这些报告病例进行总结并对两者之间的关联进行统计学分析。从1966年至2001年的医学在线数据库中，共找到14篇病例报告及2篇直接探讨GA与恶性肿瘤关系的相关性研究。病例报告中共有16例，平均年龄为54岁。大多数GA患者临床表现不典型。GA发病至发现恶性肿瘤的时间间隔从提前18个月（中位数=5个月）至之后七年（中位数=42个月）不等。超过半数的病例与淋巴瘤相关。未发现GA与恶性肿瘤之间存在明确关联。对于年龄较大、皮肤病变临床特征不典型但组织学表现类似经典GA的患者，可考虑对潜在的恶性淋巴瘤或其他恶性肿瘤进行排查。
