Barksdale S K, Perniciaro C, Halling K C, Strickler J G
Department of Dermatology, Mayo Clinic, Rochester, Minnesota.
J Am Acad Dermatol. 1994 Jul;31(1):42-8. doi: 10.1016/s0190-9622(94)70133-4.
Reports of necrobiotic granulomas or granuloma annulare in patients with malignant lymphoma are rare.
Our intent was to determine any unique clinical or histopathologic features in patients with granuloma annulare and lymphoma.
We reviewed the medical records and biopsy material from 13 patients with granuloma annulare and lymphoma.
Three patients had Hodgkin's disease and 10 had non-Hodgkin's lymphoma. The granuloma annulare lesions showed typical histopathologic features. However, the clinical pattern was frequently atypical, with painful lesions in unusual locations including the palms and soles. Three patients displayed granulomatous inflammation in noncutaneous sites, either within the malignant lymphoma or in uninvolved tissues, and all three had atypical clinical presentations of granuloma annulare.
Granuloma annulare with atypical clinical presentations may be associated with an underlying hematopoietic malignancy and may be part of a generalized granulomatous reaction to malignant lymphoma.
恶性淋巴瘤患者出现渐进性坏死性肉芽肿或环状肉芽肿的报道较为罕见。
我们旨在确定环状肉芽肿合并淋巴瘤患者的任何独特临床或组织病理学特征。
我们回顾了13例环状肉芽肿合并淋巴瘤患者的病历和活检材料。
3例患者患有霍奇金病，10例患有非霍奇金淋巴瘤。环状肉芽肿病变表现出典型的组织病理学特征。然而，临床模式通常不典型，在包括手掌和脚底等不寻常部位出现疼痛性病变。3例患者在非皮肤部位出现肉芽肿性炎症，要么在恶性淋巴瘤内，要么在未受累组织中，并且这3例患者均有环状肉芽肿的非典型临床表现。
具有非典型临床表现的环状肉芽肿可能与潜在的血液系统恶性肿瘤有关，并且可能是对恶性淋巴瘤的全身性肉芽肿反应的一部分。
