Hahn E F, Norton B I, Fishman J
Res Commun Chem Pathol Pharmacol. 1976 Apr;13(4):569-77.
Rats were injected with morphine-6(3)H diluted with increasing amounts of non-radiolabelled morphine. The entry of the isotope into the brain and various tissues was measured by combustion in a tissue oxidizer. The relative distribution of morphine between the blood and brain remained constant at about 5.5:1 over the range of doses studied (0.07 - 10.0 mg/kg). No dose related differential effects on morphine uptake were evident in central tissues, with the exception of the hypothalamus which exhibited a disproportionately greater uptake. Among the noncentral tissues, kidney and liver showed the greatest dose related increases in uptake.
给大鼠注射用越来越多的非放射性吗啡稀释的吗啡 - 6(3)H。通过在组织氧化器中燃烧来测量同位素进入大脑和各种组织的情况。在所研究的剂量范围内（0.07 - 10.0毫克/千克），血液和大脑之间吗啡的相对分布保持在约5.5:1的恒定水平。除下丘脑表现出不成比例的更大摄取外，在中枢组织中未观察到与剂量相关的对吗啡摄取的差异影响。在非中枢组织中，肾脏和肝脏显示出与剂量相关的最大摄取增加。
