Stammers B M
Res Vet Sci. 1976 Mar;20(2):174-9.
Groups of sheep were experimentally infected with Fasciola hepatica and treated with nitroxynil at 10 mg/kg given subcutaneously at intervals of up to 70 days later. Effects on fluke burden, weight, morphology, egg production and hatchability were recorded. The results showed that the efficacy of nitroxynil and the occurrence of structurally abnormal flukes were directly proportional to the age of infection at treatment. Treatment also deleteriously affected fluke growth and egg hatchability and reduced faecal egg counts.
将绵羊分组，通过实验感染肝片吸虫，然后在长达70天后每隔一段时间皮下注射10毫克/千克的硝碘酚腈进行治疗。记录对吸虫负荷、体重、形态、产卵量和孵化率的影响。结果表明，硝碘酚腈的疗效和结构异常吸虫的出现与治疗时感染的时间直接相关。治疗还对吸虫生长和卵孵化率产生有害影响，并减少粪便中的虫卵计数。
