Jarstrand C, Wasserman J
Scand J Infect Dis. 1976;8(1):7-11.
The in vitro responses to PHA (phytohemagglutinin) of lymphocytes from 14 patients with influenza A and 4 patients with influenza B infection were found decreased as compared with the responses to the same mitogen demonstrated in lymphocytes obtained from the same patients after recovery. Lymphocytes from 6 of the patients with influenza A were examined for PWM (pokeweed mitogen) stimulability and a decrease was found during the influenza infection. The decrease of PHA response during the acute stage of the disease was observed in the presence of autologous as well as of fetal calf and allogeneic AB serum. Possible mechanisms causing this impaired function of lymphocytes are discussed.
发现14例甲型流感患者和4例乙型流感患者淋巴细胞对PHA（植物血凝素）的体外反应与康复后从同一患者获得的淋巴细胞对相同促有丝分裂原的反应相比有所降低。对6例甲型流感患者的淋巴细胞进行了PWM（商陆有丝分裂原）刺激能力检测，发现在流感感染期间有所下降。在疾病急性期，无论是在自体血清、胎牛血清还是同种异体AB血清存在的情况下，PHA反应均降低。文中讨论了导致淋巴细胞功能受损的可能机制。
