Morpurgo M, Beulcke G, Colombo B, Cornelio F, Rampulla C
Schweiz Med Wochenschr. 1976 Mar 27;106(13):443-9.
Eighteen patients with myasthenia gravis, second-stage (A or B) according to Ossermann and Genkins, and of young age, were examined as outpatients from the cardiological point of view. Clinical and radiological examination of the heart and large vessels revealed no pathological features. Electrocardiographic abnormalities (including one case of ventricular preexcitation syndrome and one of subepicardial ischemia) were detected in three patients (16,6%). Among the various left ventricular systolic time intervals, only the deformation time was somewhat off normal limits in some cases, but the difference was not statistically significant. In over one-third of the cases, conversely, the kinetocardiogram revealed paradoxical systolic outward movements, indicative of myocardial dyskinesis or dissinergy. The essential normality of systolic time intervals in the presence of manifest abnormalities of the kinetocardiographic curve may be explained by the smallness of hypokinetic or dyskinetic areas, whereby the ejection fraction was not reduced. In general, the ECG and kinetocardiographic tracings showed no tendency to change under the effect of orally administered pyridostigmine.
按照奥瑟曼（Ossermann）和金金斯（Genkins）的标准，对18例重症肌无力患者进行了第二阶段（A或B）且年龄较轻患者的门诊心脏科检查。心脏和大血管的临床及放射学检查未发现病理特征。3例患者（16.6%）检测到心电图异常（包括1例心室预激综合征和1例心外膜下缺血）。在各种左心室收缩时间间期当中，只有变形时间在某些情况下略超出正常范围，但差异无统计学意义。相反，超过三分之一的病例中，心机械图显示矛盾性收缩期向外运动，提示心肌运动障碍或协同失调。在心机械图曲线明显异常的情况下，收缩时间间期基本正常，这可能是由于运动减弱或运动障碍区域较小，射血分数未降低所致。总体而言，口服吡啶斯的明后，心电图和心机械图描记图无变化趋势。
