de la Campa Adela G, Ferrandiz María-José, Tubau Fe, Pallarés Román, Manresa Federico, Liñares Josefina
Unidad de Genética Bacteriana (Consejo Superior de Investigaciones Científicas), Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Antimicrob Agents Chemother. 2003 Apr;47(4):1419-22. doi: 10.1128/AAC.47.4.1419-1422.2003.
Five Spain(9V-3) Streptococcus pneumoniae strains were isolated from a patient with bronchiectasis who had received long-term ciprofloxacin therapy. One ciprofloxacin-susceptible strain was isolated before treatment, and four ciprofloxacin-resistant strains were isolated during treatment. The resistant strains were derived from the susceptible strain either by a parC mutation (low-level resistance) or by parC and gyrA mutations (high-level resistance). This study shows that ciprofloxacin therapy in a patient colonized by susceptible S. pneumoniae may select fluoroquinolone-resistant mutants.
从一名接受长期环丙沙星治疗的支气管扩张症患者中分离出5株西班牙(9V-3)肺炎链球菌菌株。治疗前分离出1株对环丙沙星敏感的菌株，治疗期间分离出4株耐环丙沙星的菌株。耐药菌株要么通过parC突变（低水平耐药），要么通过parC和gyrA突变（高水平耐药）从敏感菌株衍生而来。本研究表明，在肺炎链球菌敏感株定植的患者中使用环丙沙星治疗可能会筛选出耐氟喹诺酮类突变体。
