肺炎球菌肺炎中氟喹诺酮类和大环内酯类治疗失败及多重耐药菌株的选择
Fluoroquinolone and macrolide treatment failure in pneumococcal pneumonia and selection of multidrug-resistant isolates.
作者信息
Pérez-Trallero Emilio, Marimon José M, Iglesias Luis, Larruskain Julián
机构信息
Servicio de Microbiología, Hospital Donostia, San Sebastián, Spain.
出版信息
Emerg Infect Dis. 2003 Sep;9(9):1159-62. doi: 10.3201/eid0909.020810.
Abstract
Streptococcus pneumoniae serotype 3, isolated from a penicillin-allergic patient and initially susceptible to fluoroquinolones, macrolides, lincosamides, quinupristin-dalfopristin, and telithromycin, became resistant to all these drugs during treatment. Mutations in the parC and gyrA and in the 23S rRNA and the ribosomal protein L22 genes were detected in the resistant isolates.
摘要
从一名对青霉素过敏的患者身上分离出的肺炎链球菌3型，最初对氟喹诺酮类、大环内酯类、林可酰胺类、奎奴普丁-达福普汀和泰利霉素敏感，但在治疗过程中对所有这些药物均产生了耐药性。在耐药菌株中检测到parC和gyrA以及23S rRNA和核糖体蛋白L22基因发生了突变。
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2
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3
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