Departamento de Microbiología Clínica, Hospital Clínico San Carlos., Plaza de Cristo Rey s/n, 28040 Madrid, Spain.
Antimicrob Agents Chemother. 2011 May;55(5):2469-71. doi: 10.1128/AAC.01380-10. Epub 2011 Mar 7.
Among 1,349 Streptococcus pneumoniae invasive isolates, 45 (3.3%) were levofloxacin resistant. Serotype distribution was as follows: 8 (n=32 isolates), 19A (n=4 isolates), 7F (n=3 isolates), 9V (n=2 isolates), 10A (n=1 isolate), 19F (n=1 isolate), 6B (n=1 isolate), and nontypeable (n=1 isolate). Levofloxacin-resistant isolates had dual mutations in the gyrA and parC genes. Serotype 8 strains corresponded to a capsular switching of the Sweden(15A)-25 clone. Levofloxacin resistance was also detected among multiresistant (ST276(19A), Spain9V-ST156, ST88(19F), and ST1542(6B)) and among usually antibiotic-susceptible (Netherlands7F-ST191, ST1201(19A), and ST2639(10A)) clones.
在 1349 株肺炎链球菌侵袭性分离株中，有 45 株（3.3%）对左氧氟沙星耐药。血清型分布如下：8 型（n=32 株分离株）、19A 型（n=4 株）、7F 型（n=3 株）、9V 型（n=2 株）、10A 型（n=1 株）、19F 型（n=1 株）、6B 型（n=1 株）和非定型（n=1 株）。左氧氟沙星耐药分离株在 gyrA 和 parC 基因中存在双重突变。8 型菌株与瑞典（15A）-25 克隆的荚膜转换相对应。在多耐药（ST276（19A）、西班牙 9V-ST156、ST88（19F）和 ST1542（6B））和通常抗生素敏感（荷兰 7F-ST191、ST1201（19A）和 ST2639（10A））克隆中也检测到左氧氟沙星耐药。
