2007 年至 2009 年西班牙马德里地区耐左氧氟沙星肺炎链球菌侵袭性分离株的克隆传播。
Clonal spread of levofloxacin-resistant streptococcus pneumoniae invasive isolates in Madrid, Spain, 2007 to 2009.
机构信息
Departamento de Microbiología Clínica, Hospital Clínico San Carlos., Plaza de Cristo Rey s/n, 28040 Madrid, Spain.
出版信息
Antimicrob Agents Chemother. 2011 May;55(5):2469-71. doi: 10.1128/AAC.01380-10. Epub 2011 Mar 7.
Abstract
Among 1,349 Streptococcus pneumoniae invasive isolates, 45 (3.3%) were levofloxacin resistant. Serotype distribution was as follows: 8 (n=32 isolates), 19A (n=4 isolates), 7F (n=3 isolates), 9V (n=2 isolates), 10A (n=1 isolate), 19F (n=1 isolate), 6B (n=1 isolate), and nontypeable (n=1 isolate). Levofloxacin-resistant isolates had dual mutations in the gyrA and parC genes. Serotype 8 strains corresponded to a capsular switching of the Sweden(15A)-25 clone. Levofloxacin resistance was also detected among multiresistant (ST276(19A), Spain9V-ST156, ST88(19F), and ST1542(6B)) and among usually antibiotic-susceptible (Netherlands7F-ST191, ST1201(19A), and ST2639(10A)) clones.
摘要
在 1349 株肺炎链球菌侵袭性分离株中，有 45 株（3.3%）对左氧氟沙星耐药。血清型分布如下：8 型（n=32 株分离株）、19A 型（n=4 株）、7F 型（n=3 株）、9V 型（n=2 株）、10A 型（n=1 株）、19F 型（n=1 株）、6B 型（n=1 株）和非定型（n=1 株）。左氧氟沙星耐药分离株在 gyrA 和 parC 基因中存在双重突变。8 型菌株与瑞典（15A）-25 克隆的荚膜转换相对应。在多耐药（ST276（19A）、西班牙 9V-ST156、ST88（19F）和 ST1542（6B））和通常抗生素敏感（荷兰 7F-ST191、ST1201（19A）和 ST2639（10A））克隆中也检测到左氧氟沙星耐药。
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