Leigh D A, Simmons K
Scott Med J. 1976 Sep;20(5):228-31. doi: 10.1177/003693307502000510.
The antibiotic sensitivity of 50 strains of Bacteroides fragilis to four cephalosporin compounds, cephazolin, cephaloridine, cephradine and cephalexin is reported. Cephazolin was found to be the most active, 94 per cent of strains being susceptible to blood concentrations achieved on standard dosage, comparative findings with cephaloridine and cephradine were about 50 per cent, and only 22 per cent of strains were inhibited by cephalexin. The importance of infections due to bacteroides is discussed. Although not the treatment of choice, cephazolin, a view of its bacterial activity may be useful alternative for bacteroides infections but clinical trials are needed to confirm the laboratory results.
本文报告了50株脆弱拟杆菌对4种头孢菌素类化合物（头孢唑林、头孢噻啶、头孢拉定和头孢氨苄）的抗生素敏感性。结果发现头孢唑林活性最强，94%的菌株对标准剂量下所能达到的血药浓度敏感；头孢噻啶和头孢拉定的相应结果约为50%；而只有22%的菌株被头孢氨苄抑制。文中讨论了拟杆菌属感染的重要性。虽然头孢唑林并非首选治疗药物，但鉴于其抗菌活性，它可能是治疗拟杆菌属感染的一种有用替代药物，但需要进行临床试验来证实实验室结果。
