Kilpatrick M, Cesario T C, Thrupp L, Tilles J G
Scott Med J. 1976 Sep;20(5):248-54. doi: 10.1177/003693307502000515.
Ten cases of pneumococcal pneumonia were treated with cephazolin 500 mg. q8h for at least 5 days. In every case therapy was accompanied by clinical improvement and eradication of the organism. Ten patients with E. coli bacteriuria (5 symptomatic) were treated with cephazolin 500 mg. q12h for 7 to 10 days. In every case the pathogen was eliminated during therapy but in one case bacteriologic relapse occurred following cessation of therapy. In 10 cases of bacteriuria caused by P. mirabilis, Klebsiella sp, Enterobacter, and Enterococcus, the urine became sterile during treatment, but relapse was common. Initial and final creatinine clearances obtained in 29 patients who received an average of 12.9 g. of cephazolin showed no tendency toward loss of renal function. Serial serum levels of cephazolin were determined following the first 500 mg. dose in 18 patients. The peak serum level occurred at one hour with a serum half life of approximately 2.2 hours. For 13 of these 18 patients serial serum levels were also obtained following the last dose of cephazolin. At this time the mean peak level occurred at 2 hours but again the serum half life was approximately 1.9 hours.
10例肺炎球菌肺炎患者接受头孢唑林治疗，剂量为500毫克，每8小时一次，至少治疗5天。每例患者治疗后临床症状均有改善，病原体被清除。10例大肠杆菌性菌尿患者（5例有症状）接受头孢唑林治疗，剂量为500毫克，每12小时一次，治疗7至10天。每例患者治疗期间病原体均被清除，但1例患者治疗停止后出现细菌学复发。在10例由奇异变形杆菌、克雷伯菌属、肠杆菌属和肠球菌引起的菌尿患者中，治疗期间尿液变为无菌，但复发很常见。29例平均接受12.9克头孢唑林治疗的患者，最初和最后的肌酐清除率显示肾功能无下降趋势。对18例患者首次给予500毫克剂量的头孢唑林后测定了系列血清水平。血清峰值水平在1小时出现，血清半衰期约为2.2小时。这18例患者中有13例在最后一剂头孢唑林后也测定了系列血清水平。此时平均峰值水平在2小时出现，但血清半衰期再次约为1.9小时。
