Petit J F, Wietzerbin J, Das B C, Lederer E
Z Immunitatsforsch Exp Klin Immunol. 1975 Jul;149(2-4):118-25.
BCG cell walls contain approximately 30% free lipids like other mycobacterial cell walls. The insoluble skeleton of the cell wall is made up of two covalently linked polymers, a peptidoglycan and an arabinogalactan mycolate, with which are associated non peptidoglycan amino acids and a glucan. We present data on two structural features: 1. The "non peptidoglycan" amino acids; they form two kinds of compounds: peptide chains which can be solubilized by proteolytic enzymes and a trypsin-chymotrypsin insensitive poly-alpha-L-glutamic acid. 2. Presence of meso-DAP-meso-DAP1) interpeptide linkages in the peptidoglycan: this new type represents at least 50% of the interpeptide linkages of the cell wall of the BCG strain.
卡介苗细胞壁与其他分枝杆菌细胞壁一样，含有约30%的游离脂质。细胞壁的不溶性骨架由两种共价连接的聚合物组成，一种是肽聚糖，另一种是阿拉伯半乳聚糖霉菌酸，与之相关联的还有非肽聚糖氨基酸和一种葡聚糖。我们展示了关于两个结构特征的数据：1. “非肽聚糖”氨基酸；它们形成两种化合物：可被蛋白水解酶溶解的肽链和对胰蛋白酶-胰凝乳蛋白酶不敏感的聚-α-L-谷氨酸。2. 肽聚糖中存在内消旋二氨基庚二酸-内消旋二氨基庚二酸（meso-DAP-meso-DAP1）肽间连接：这种新类型至少占卡介苗菌株细胞壁肽间连接的50%。
