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Vector priming reduces the immunogenicity of Salmonella-based vaccines in Nramp1+/+ mice.载体启动可降低Nramp1+/+小鼠中基于沙门氏菌的疫苗的免疫原性。
Infect Immun. 2003 Apr;71(4):2258-61. doi: 10.1128/IAI.71.4.2258-2261.2003.
2
Vector-primed mice display hypo-responsiveness to foreign antigen presented by recombinant Salmonella regardless of the route of delivery.载体引发的小鼠对重组沙门氏菌呈递的外来抗原表现出低反应性，无论递送途径如何。
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Subcutaneous vaccination with attenuated Salmonella enterica serovar Choleraesuis C500 expressing recombinant filamentous hemagglutinin and pertactin antigens protects mice against fatal infections with both S. enterica serovar Choleraesuis and Bordetella bronchiseptica.用表达重组丝状血凝素和百日咳杆菌粘附素抗原的减毒肠炎沙门氏菌猪霍乱血清型C500进行皮下接种，可保护小鼠免受猪霍乱沙门氏菌和支气管败血波氏杆菌的致命感染。
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Impact of vector priming on the immunogenicity of recombinant Salmonella vaccines.载体预激发对重组沙门氏菌疫苗免疫原性的影响。
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Oral immunization with ATP-dependent protease-deficient mutants protects mice against subsequent oral challenge with virulent Salmonella enterica serovar typhimurium.用ATP依赖性蛋白酶缺陷型突变体进行口服免疫可保护小鼠免受随后用毒力鼠伤寒沙门氏菌进行的口服攻击。
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3
Influence of promoter, gene copy number, and preexisting immunity on humoral and cellular responses to a vectored antigen delivered by a Salmonella enterica vaccine.启动子、基因拷贝数和预先存在的免疫力对肠道沙门氏菌疫苗递送的载体抗原的体液和细胞免疫反应的影响。
Clin Vaccine Immunol. 2009 Jan;16(1):78-87. doi: 10.1128/CVI.00253-08. Epub 2008 Nov 12.
4
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5
Enteric pathogens as vaccine vectors for foreign antigen delivery.作为用于递送外源抗原的疫苗载体的肠道病原体。
Infect Immun. 2004 Oct;72(10):5535-47. doi: 10.1128/IAI.72.10.5535-5547.2004.

本文引用的文献

1
Impact of vector priming on the immunogenicity of recombinant Salmonella vaccines.载体预激发对重组沙门氏菌疫苗免疫原性的影响。
Infect Immun. 2003 Jan;71(1):287-97. doi: 10.1128/IAI.71.1.287-297.2003.
2
Nramp1 modifies the fusion of Salmonella typhimurium-containing vacuoles with cellular endomembranes in macrophages.Nramp1调节巨噬细胞中含鼠伤寒沙门氏菌液泡与细胞内膜的融合。
J Biol Chem. 2002 Jan 18;277(3):2258-65. doi: 10.1074/jbc.M105508200. Epub 2001 Nov 7.
3
Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions.天然抗性相关巨噬细胞蛋白（NRAMP）家族蛋白在宿主-病原体相互作用界面上对二价金属离子的转运
Trends Microbiol. 2001 Aug;9(8):397-403. doi: 10.1016/s0966-842x(01)02098-4.
4
Effect of preexisting immunity to Salmonella on the immune response to recombinant Salmonella enterica serovar typhimurium expressing a Porphyromonas gingivalis hemagglutinin.对沙门氏菌的既有免疫力对表达牙龈卟啉单胞菌血凝素的重组鼠伤寒沙门氏菌免疫反应的影响。
Infect Immun. 2000 Jun;68(6):3116-20. doi: 10.1128/IAI.68.6.3116-3120.2000.
5
Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers.减毒伤寒沙门氏菌口服活载体疫苗CVD 908-htrA在美国志愿者中的2期临床试验。
Infect Immun. 2000 Mar;68(3):1196-201. doi: 10.1128/IAI.68.3.1196-1201.2000.
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Host cytokine response and resistance to Salmonella infection.宿主细胞因子反应与对沙门氏菌感染的抵抗力。
Microbes Infect. 1999 Jul;1(9):719-26. doi: 10.1016/s1286-4579(99)80073-2.
7
Prior immunity to homologous and heterologous Salmonella serotypes suppresses local and systemic anti-fragment C antibody responses and protection from tetanus toxin in mice immunized with Salmonella strains expressing fragment C.对同源和异源沙门氏菌血清型的预先免疫会抑制在用表达C片段的沙门氏菌菌株免疫的小鼠中局部和全身抗C片段抗体反应以及对破伤风毒素的保护作用。
Infect Immun. 1999 Aug;67(8):3810-5. doi: 10.1128/IAI.67.8.3810-3815.1999.
8
Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7.Nramp1在小鼠巨噬细胞系RAW264.7中的体外功能表达。
Infect Immun. 1999 May;67(5):2225-32. doi: 10.1128/IAI.67.5.2225-2232.1999.
9
Genetic control of immune response to recombinant antigens carried by an attenuated Salmonella typhimurium vaccine strain: Nramp1 influences T-helper subset responses and protection against leishmanial challenge.减毒鼠伤寒沙门氏菌疫苗株携带的重组抗原免疫应答的遗传控制：Nramp1影响辅助性T细胞亚群应答及对利什曼原虫攻击的抵抗力。
Infect Immun. 1998 May;66(5):1910-7. doi: 10.1128/IAI.66.5.1910-1917.1998.
10
The immune response to a B-cell epitope delivered by Salmonella is enhanced by prior immunological experience.沙门氏菌传递的B细胞表位的免疫反应会因先前的免疫经历而增强。
Vaccine. 1997 Nov;15(16):1737-40. doi: 10.1016/s0264-410x(97)00119-9.

载体启动可降低Nramp1+/+小鼠中基于沙门氏菌的疫苗的免疫原性。

Vector priming reduces the immunogenicity of Salmonella-based vaccines in Nramp1+/+ mice.

作者信息

Vindurampulle Christofer J, Attridge Stephen R

机构信息

Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.

出版信息

Infect Immun. 2003 Apr;71(4):2258-61. doi: 10.1128/IAI.71.4.2258-2261.2003.

DOI:10.1128/IAI.71.4.2258-2261.2003
PMID:12654852
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC152061/
Abstract

The present studies in Nramp1(-/-) BALB/c and Nramp1(+/+) CBA mice question the significance of this genotype as a determinant of the level of gut colonization following oral administration of naturally attenuated or highly virulent Salmonella strains. In line with previous results in BALB/c hosts, vector priming of CBA mice with Salmonella enterica serovar Stanley was found to significantly compromise the immunogenicity of a recombinant construct expressing a foreign pilus protein.

摘要

在Nramp1(-/-) BALB/c小鼠和Nramp1(+/+) CBA小鼠中开展的当前研究，对这种基因型作为口服天然减毒或高毒力沙门氏菌菌株后肠道定殖水平的决定因素的重要性提出了质疑。与之前在BALB/c宿主中获得的结果一致，发现用肠炎沙门氏菌斯坦利血清型对CBA小鼠进行载体启动，会显著损害表达外源菌毛蛋白的重组构建体的免疫原性。