载体启动可降低Nramp1+/+小鼠中基于沙门氏菌的疫苗的免疫原性。
Vector priming reduces the immunogenicity of Salmonella-based vaccines in Nramp1+/+ mice.
作者信息
Vindurampulle Christofer J, Attridge Stephen R
机构信息
Department of Molecular Biosciences, The University of Adelaide, Adelaide, South Australia 5005, Australia.
出版信息
Infect Immun. 2003 Apr;71(4):2258-61. doi: 10.1128/IAI.71.4.2258-2261.2003.
Abstract
The present studies in Nramp1(-/-) BALB/c and Nramp1(+/+) CBA mice question the significance of this genotype as a determinant of the level of gut colonization following oral administration of naturally attenuated or highly virulent Salmonella strains. In line with previous results in BALB/c hosts, vector priming of CBA mice with Salmonella enterica serovar Stanley was found to significantly compromise the immunogenicity of a recombinant construct expressing a foreign pilus protein.
摘要
在Nramp1(-/-) BALB/c小鼠和Nramp1(+/+) CBA小鼠中开展的当前研究，对这种基因型作为口服天然减毒或高毒力沙门氏菌菌株后肠道定殖水平的决定因素的重要性提出了质疑。与之前在BALB/c宿主中获得的结果一致，发现用肠炎沙门氏菌斯坦利血清型对CBA小鼠进行载体启动，会显著损害表达外源菌毛蛋白的重组构建体的免疫原性。
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