Whittle B L, Verma N K
Division of Biochemistry and Molecular Biology, Australian National University, Canberra, Australia.
Vaccine. 1997 Nov;15(16):1737-40. doi: 10.1016/s0264-410x(97)00119-9.
Attenuated, heterologous strains of Salmonella have shown potential as live, recombinant vaccines against foreign pathogens. Studies in animal models have demonstrated that immunization with these heterologous vaccines is an effective way to induce both cellular and humoral immune responses against Salmonella and the foreign antigen. We studied the consequence of priming mice with Salmonella dublin 3-6 months before intraperitoneal administration with the same strain carrying a model B-cell epitope. Mice primed with the carrier strain demonstrated enhanced serum Ig titres against the foreign antigen. This immune enhancement was observed up to approximately 6 months after priming. These findings suggest that previous immunological experience with Salmonella does not limit the immune response to a foreign antigen carried by the same organism. In fact, prior exposure to Salmonella appears to enhance the response to the foreign antigen.
减毒的沙门氏菌异源菌株已显示出作为针对外来病原体的活重组疫苗的潜力。在动物模型中的研究表明，用这些异源疫苗进行免疫是诱导针对沙门氏菌和外来抗原的细胞免疫和体液免疫反应的有效方法。我们研究了在腹腔注射携带模型B细胞表位的同一菌株前3至6个月用都柏林沙门氏菌对小鼠进行预免疫的后果。用载体菌株预免疫的小鼠针对外来抗原的血清Ig滴度有所提高。这种免疫增强在预免疫后约6个月内都能观察到。这些发现表明，先前对沙门氏菌的免疫经历并不限制对同一生物体携带的外来抗原的免疫反应。事实上，先前接触沙门氏菌似乎会增强对外来抗原的反应。
