Alebiosu C O, Ogunledun A, Ogunleye D S
Depqrtment of Medicine, Ogun State University Teaching Hospital, Ibadan, Nigeria.
J Natl Med Assoc. 2003 Jan;95(1):95-105.
The efficacy of Toto ointment and soap on common skin disorders was tested.
A cohort of Nigerians with common skin conditions such as fungal and bacterial skin infections, scabies, acne vulgaris, and dandruff were selected and followed for a period of 12 weeks. The study is a randomized, comparative, prospective, blinded observational study. Following a placebo run in/wash out period, patients were given either a Toto ointment or soap, or a combination of these, or sulfur ointment alone. Soap use was preferred in patients with Tinea capitis more than patients with any other superficial skin condition for technical reasons--such as ease of application of the soap lather. Expressed preference for either the soap or the cream was at times taken into consideration. Cure rate, adverse drug effects and acceptability of the products were assessed.
Out of the 595 patients with common skin diseases selected for the study, 446 (74.9%) had fungal infections, while 64 (10.8%) had scabies infestation. A total of 47 (7.9%) patients had bacterial skin infections, 36 (6.1%) had acne vulgaris, and two (0.3%) had dandruff. At the end of the treatment period, out of the 129 patients with fungal infections treated with Toto ointment alone, 92 (71.3)% were successfully treated; while 41 (87.2%) out of the 47 patients with scabies were successfully treated with Toto ointment alone. Although few patients were seen with bacterial skin infections during the study period, these patients responded well to the ointment, the soap or a combination of the two. Overall, the combination of Toto ointment and soap had a better clinical success rate on all diseases when compared to sulfur ointment alone. The study has shown the efficacy and tolerability of Toto products (skin ointment and soap) in the management of common skin disorders.
Toto ointment and soap are particularly efficacious in the management of common skin conditions such as fungal and bacterial skin infections, scabies, acne vulgaris and dandruff.
测试托托软膏和肥皂对常见皮肤疾病的疗效。
选取一组患有常见皮肤疾病（如真菌和细菌皮肤感染、疥疮、寻常痤疮和头皮屑）的尼日利亚人，随访12周。该研究是一项随机、对比、前瞻性、盲法观察性研究。在经过安慰剂导入/洗脱期后，患者被给予托托软膏或肥皂，或两者的组合，或单独的硫磺软膏。由于技术原因，如易于涂抹肥皂泡沫，头癣患者比其他任何浅表皮肤疾病患者更倾向于使用肥皂。有时会考虑患者对肥皂或乳膏的明确偏好。评估了治愈率、药物不良反应和产品的可接受性。
在入选该研究的595例常见皮肤疾病患者中，446例（74.9%）患有真菌感染，64例（10.8%）患有疥疮感染。共有47例（7.9%）患者患有细菌性皮肤感染，36例（6.1%）患有寻常痤疮，2例（0.3%）患有头皮屑。在治疗期结束时，仅用托托软膏治疗的129例真菌感染患者中，92例（71.3%）得到成功治疗；而仅用托托软膏治疗的47例疥疮患者中，41例（87.2%）得到成功治疗。尽管在研究期间很少有患者出现细菌性皮肤感染，但这些患者对软膏、肥皂或两者的组合反应良好。总体而言，与单独使用硫磺软膏相比，托托软膏和肥皂的组合对所有疾病的临床成功率更高。该研究表明了托托产品（皮肤软膏和肥皂）在治疗常见皮肤疾病方面的疗效和耐受性。
托托软膏和肥皂在治疗常见皮肤疾病（如真菌和细菌皮肤感染、疥疮、寻常痤疮和头皮屑）方面特别有效。
