甾体环磷酰胺的合成。
Synthesis of steroidal cyclophosphamides.
作者信息
Foster E L, Blickenstaff R T
出版信息
Steroids. 1976 Mar;27(3):353-60. doi: 10.1016/0039-128x(76)90056-8.
PMID:1265797
Abstract
The Reformatsky product of estrone methyl ether and ethyl bromo-acetate was transformed by two separate routes to 21-amino-3-methoxy-17alpha-pregna-1,3,5(10)-trien-17beta-ol (9). Cyclization with bis- (2-chloroethyl) phosphoramide dichloride produced the steroidal cyclophosphamide 10. Analogous syntheses transformed androstenolone into steroidal cyclophosphamide 20 and androstenedione into steroidal cyclophosphamide 28.
摘要
雌酮甲醚与溴乙酸乙酯的雷福马斯基产物通过两条不同路线转化为21-氨基-3-甲氧基-17α-孕甾-1,3,5(10)-三烯-17β-醇（9）。与双（2-氯乙基）磷酰胺二氯化物环化生成甾体环磷酰胺10。类似的合成方法将雄烯醇酮转化为甾体环磷酰胺20，将雄烯二酮转化为甾体环磷酰胺28。
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