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引用本文的文献

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本文引用的文献

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[Specific chemotherapy of carcinoma of the prostate].[前列腺癌的特异性化疗]
Klin Wochenschr. 1952 Oct 1;30(37-38):882-4. doi: 10.1007/BF01471475.
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Examination of newly synthesized 2-chloroethyl-nitrosoureas on rat leukemia L 5222.新型合成的2-氯乙基亚硝基脲对大鼠白血病L 5222的研究。
Oncology. 1981;38(1):39-42. doi: 10.1159/000225519.
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Chemotherapeutic activity of 2-chloroethylnitrosocarbamoyl derivatives of amino acids in a transplanted rat leukemia (L 5222).氨基酸的2-氯乙基亚硝基氨基甲酰衍生物对移植大鼠白血病（L 5222）的化疗活性
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Therapeutic and prognostic implications of glucocorticoid receptors and terminal deoxynucleotidyl transferase in acute leukemia.
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Studies on the mechanism of action of LS 1727, a nitrosocarbamate of 19-nortestosterone.关于19-去甲睾酮亚硝基氨基甲酸酯LS 1727作用机制的研究。
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Steroidal alkylating agents. I. Some 16-substituted androstanes and pregnanes.甾体烷基化剂。I. 一些16-取代雄甾烷和孕甾烷。
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7
The effects of some steroidal alkylating agents on experimental animal mammary tumor and leukemia systems.某些甾体烷基化剂对实验动物乳腺肿瘤和白血病系统的影响。
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Steroids and steroidases. 10. Studies on some potentially antitumor active androstane compounds containing C-17 nitrogen mustard functions.类固醇与类固醇酶。10. 对一些含有C-17氮芥官能团的潜在抗肿瘤活性雄甾烷化合物的研究。
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9
Treatment in vivo of R3230AC carcinoma of the rat with estradiol mustard (NSC-112259) of its molecular components.用雌二醇氮芥（NSC - 112259）及其分子成分对大鼠R3230AC癌进行体内治疗。
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甾体连接亚硝基脲的细胞生长抑制活性。

Cytostatic activity of steroid linked nitrosoureas.

作者信息

Zeller W J, Schreiber J, Ho A D, Schmähl D, Eisenbrand G

出版信息

J Cancer Res Clin Oncol. 1984;108(1):164-8. doi: 10.1007/BF00390991.

DOI:10.1007/BF00390991
PMID:6746709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12252638/
Abstract

First investigations on the therapeutic activity of a new group of steroid-linked N-(2-chloroethyl)-N-nitrosocarbamoyl-L-alanine esters (CNC-L-alanine esters) in a nitrosourea-sensitive rat leukemia (L 5222) characterized by a relatively high content of glucocorticoid binding sites are presented. Despite a considerable range of optimal and toxic doses of the different analogs, the respective therapeutic ratios do not appear to be significantly influenced by the nature of the carrier molecules to which CNC-L-alanine is attached. However several steroid-linked representatives are distinctly more active than CNC-L-alanine. The androsterone-3-ester and the dihydrotestosterone-17-ester, in particular effected high percentages of cures in contrast to CNC-L-alanine.

摘要

首次对一组新的与甾体相连的N-(2-氯乙基)-N-亚硝基氨基甲酰-L-丙氨酸酯（CNC-L-丙氨酸酯）在一种对亚硝基脲敏感的大鼠白血病（L 5222）中的治疗活性进行了研究，该白血病的糖皮质激素结合位点含量相对较高。尽管不同类似物的最佳剂量和毒性剂量范围相当大，但各自的治疗比率似乎并未受到与CNC-L-丙氨酸相连的载体分子性质的显著影响。然而，几种与甾体相连的代表物明显比CNC-L-丙氨酸更具活性。尤其是雄甾酮-3-酯和双氢睾酮-17-酯，与CNC-L-丙氨酸相比，实现了高治愈率。