Sanchis-Gimeno Juan A, Lleó A, Alonso L, Rahhal M S, Martínez-Soriano F
Department of Anatomy and Human Embryology, University of Valencia, Faculty of Medicine, Spain.
Cornea. 2003 Apr;22(3):243-5. doi: 10.1097/00003226-200304000-00012.
To study the differences in the corneal anatomy in a pair of 31-year-old monozygotic female twins, one of whom has been a contact lens wearer for the past 15 years and the other is a nonwearer.
We analyzed the corneal thickness and the corneal endothelial cell density of the monozygotic twins and of two age-matched control groups, one made up of non-contact lens wearers (35 eyes of 35 patients; mean age, 29.32 +/- 2.83 years) and the other made up of soft contact lens wearers (30 eyes of 30 patients; mean age, 33.08 +/- 3.72 years; mean duration of contact lens use, 10.62 +/- 4.32 years). Five corneal thickness measurements were carried out with the Orbscan Topography System II. Three consecutive measurements of the corneal endothelial cell density were carried out with the Topcon SP-2000P noncontact specular microscope.
Lower central corneal endothelial cell densities were found in both eyes of the monozygotic contact lens-wearing twin. The greater corneal thickness was shown at superonasal cornea except in the right cornea of the monozygotic contact lens twin. Moreover, significant differences in corneal thickness values were found between the monozygotic twins.
The differences between the monozygotic twins seem to confirm that daily use of soft contact lenses can modify normal corneal anatomy.
研究一对31岁的单卵双生女性双胞胎的角膜解剖结构差异，其中一人在过去15年一直佩戴隐形眼镜，另一人不佩戴。
我们分析了这对单卵双胞胎以及两个年龄匹配的对照组的角膜厚度和角膜内皮细胞密度，一个对照组由非隐形眼镜佩戴者组成（35例患者的35只眼；平均年龄，29.32±2.83岁），另一个对照组由软性隐形眼镜佩戴者组成（30例患者的30只眼；平均年龄，33.08±3.72岁；平均隐形眼镜使用时长，10.62±4.32年）。使用Orbscan Topography System II进行5次角膜厚度测量。使用Topcon SP - 2000P非接触式角膜内皮显微镜连续3次测量角膜内皮细胞密度。
在单卵双生且佩戴隐形眼镜的双胞胎的双眼均发现中央角膜内皮细胞密度较低。除了单卵双生且佩戴隐形眼镜的双胞胎的右眼外，在鼻上方角膜处显示出更大的角膜厚度。此外，在这对单卵双胞胎之间发现角膜厚度值存在显著差异。
单卵双胞胎之间的差异似乎证实了每日佩戴软性隐形眼镜会改变正常的角膜解剖结构。
