Optometry and Vision Science Program & Research Centre for Community Health, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Malaysia.
Optometry and Vision Science Program & Research Centre for Community Health, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Malaysia.
Cont Lens Anterior Eye. 2021 Feb;44(1):72-75. doi: 10.1016/j.clae.2020.06.007. Epub 2020 Jul 2.
To analyse and compare the alterations in corneal endothelium morphology induced by different materials and durations of wearing soft contact lenses (CL) among young adults living in Kuala Lumpur.
Healthy soft CL wearers were invited to participate in this study. Visual acuity (VA) was measured using the Snellen chart, and subjective refraction was performed using cross-cylinder technique. Standard ocular assessments were conducted using a slit lamp biomicroscope and morphology of corneal endothelial cells (endothelial cell density, ECD, coefficient variation, COV, hexagonality, HEX and central corneal thickness, CCT) were evaluated using a non-contact specular microscope. Statistical analysis was conducted using ANOVA and data from the right eye only is included.
A total of 72 subjects (32 SiHy and 40 HCL wearers) and 24 non-CL wearers (control) participated in this study. The gender distribution for study subjects was 13 males and 59 females, with a mean age 22.15 ± 1.84 years old. The mean refraction was -1.86 ± 1.25DS. The duration of wearing CL ranged from 1 to 9 years. Subjects were later divided into 2 groups following duration of CL wear: Group 1 (<5 years) and Group 2 (≥5 years) for analysis purposes. Statistical analysis showed significant alterations in ECD, COV and HEX of CL wearers (p < 0.05), with more changes found in HCL and Group 2 wearers. No significant change was found in CCT.
This study concludes that soft CL wear induced alterations in the morphology of corneal endothelial cells. Contact lens material and duration of CL wear (in years) are factors that affect the alterations. Optometrists are recommended to regularly evaluate the morphology of corneal endothelial cells in CL wearers and provide necessary intervention when required.
分析和比较不同材料和软性隐形眼镜（CL）佩戴时间对吉隆坡年轻成年人角膜内皮细胞形态的影响。
邀请健康的软性 CL 佩戴者参与本研究。使用 Snellen 图表测量视力（VA），使用交叉圆柱技术进行主观验光。使用裂隙灯生物显微镜进行标准眼部评估，并使用非接触式共焦显微镜评估角膜内皮细胞形态（内皮细胞密度，ECD，变异系数，COV，六边形，HEX 和中央角膜厚度，CCT）。使用方差分析进行统计分析，仅纳入右眼数据。
共有 72 名受试者（32 名 SiHy 和 40 名 HCL 佩戴者）和 24 名非 CL 佩戴者（对照组）参与了本研究。研究对象的性别分布为 13 名男性和 59 名女性，平均年龄为 22.15±1.84 岁。平均屈光度为-1.86±1.25DS。CL 的佩戴时间从 1 年到 9 年不等。随后根据 CL 佩戴时间将受试者分为 2 组进行分析：第 1 组（<5 年）和第 2 组（≥5 年）。统计分析显示 CL 佩戴者的 ECD、COV 和 HEX 发生了显著变化（p<0.05），其中 HCL 和第 2 组佩戴者的变化更为明显。CCT 无明显变化。
本研究表明软性 CL 佩戴会引起角膜内皮细胞形态的改变。接触镜材料和 CL 佩戴时间（年）是影响变化的因素。建议验光师定期评估 CL 佩戴者的角膜内皮细胞形态，并在需要时提供必要的干预。
