Gunzerath Lorraine, Goldman David
NIAAA Office of Scientific Affairs, National Institutes of Health, 6000 Executive Blvd., Suite 409, Bethesda, MD 20892-7003, USA.
Alcohol Clin Exp Res. 2003 Mar;27(3):540-62. doi: 10.1097/01.ALC.0000057944.57330.65.
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) sponsored a May 2002 workshop on gene-environment interaction (G x E) research to identify potential roadblocks to further research and to propose solutions to those roadblocks, to optimize investigative opportunities and multidisciplinary or multi-institution collaborations, and to explore ways that NIAAA can facilitate G x E studies. Sessions included panels on animal models; phenotypes; genetic findings in humans; study designs and analytical methods; and assessment of environmental risk. Key among the identified challenges to progress in G x E research were issues of study design and sampling strategies; logistic and methodological costs and constraints; availability and understanding of data analysis techniques; potential stigmatization of study populations; and organizational/bureaucratic structures that are inadequate to address the unique needs of large-scale, multicenter, longitudinal projects. Participants proposed a series of recommendations to address these issues. Session coordinators included: Gayle Boyd, Kendall Bryant, Page Chiapella, Vivian Faden, David Goldman, and Antonio Noronha. Session participants included: Laura Almasy, Henri Begleiter, Raul Caetano, Bruce Dudek, Mary Dufour, Cindy Ehlers, Mary-Anne Enoch, Joel Gelernter, David Goldman, Bridget Grant, Lorraine Gunzerath, Deborah Hasin, Andrew Heath, Victor Hesselbrock, J. Dee Higley, Shirley Hill, Kerry Jang, Raynard S. Kington, Rick Kittles, George Koob, Kenneth Leonard, Ting-Kai Li, Jeffrey Long, William McBride, Matthew McGue, Kathleen Merikangas, Tamara Phillips, Bernice Porjesz, Carol Prescott, Theodore Reich, John Rice, Richard Rose, Charmaine Royal, Arnold Sameroff, Marc Schuckit, Kenneth Sher, Renee Sieving, Robert Taylor, Michael Windle, and Robert Zucker.
美国国立酒精滥用与酒精中毒研究所(NIAAA)于2002年5月主办了一次关于基因-环境相互作用(G x E)研究的研讨会,以确定进一步研究的潜在障碍并提出解决这些障碍的方案,优化调查机会和多学科或多机构合作,并探索NIAAA促进G x E研究的方式。会议包括关于动物模型、表型、人类基因研究结果、研究设计和分析方法以及环境风险评估的小组讨论。在确定的G x E研究进展挑战中,关键问题包括研究设计和抽样策略、后勤和方法成本及限制、数据分析技术的可用性和理解、研究人群可能受到的污名化以及不足以满足大规模、多中心、纵向项目独特需求的组织/官僚结构。与会者提出了一系列建议来解决这些问题。会议协调人包括:盖尔·博伊德、肯德尔·布莱恩特、佩奇·恰佩拉、维维安·法登、大卫·戈德曼和安东尼奥·诺罗尼亚。会议参与者包括:劳拉·阿尔马西、亨利·贝格莱特、劳尔·卡埃塔诺、布鲁斯·杜德克、玛丽·杜福尔、辛迪·埃勒斯、玛丽-安妮·伊诺克、乔尔·盖勒恩特、大卫·戈德曼、布里奇特·格兰特、洛林·冈泽拉特、黛博拉·哈辛、安德鲁·希思、维克多·赫塞尔布罗克、J. 迪·希格利、雪莉·希尔、克里·张、雷纳德·S. 金顿、里克·基特尔斯、乔治·库布、肯尼斯·伦纳德、丁凯·李、杰弗里·朗、威廉·麦克布赖德、马修·麦圭尔、凯瑟琳·梅里康加斯、塔玛拉·菲利普斯、伯尼斯·波耶什、卡罗尔·普雷斯科特、西奥多·赖克、约翰·赖斯、理查德·罗斯、查曼·罗亚尔、阿诺德·萨梅罗夫、马克·舒基特、肯尼斯·谢尔、蕾妮·西文、罗伯特·泰勒、迈克尔·温德尔和罗伯特·朱克。