Wang Yun-jiao, Cheng Zhi-gang, Guo Qu-lain
Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha 410008, China.
Hunan Yi Ke Da Xue Xue Bao. 2002 Dec 28;27(6):545-6.
To observe the prophylactic effect of granisetron on postoperative nausea and vomiting (PONV) after supratentorial craniotomy.
Seventy ASA I-II patients undergoing elective supratentorial craniotomy were randomly and double-bindly divided into two groups: control group (Group C, n = 35) and granisetron group (Group G, n = 35). All the patients received either 0.9% NS (Group C) or granisetron 3 mg (Group G) via intravenous injection. The incidences of postoperative nausea and vomiting were recorded at 24 h, 48 h, 72 h after supratentorial craniotomy.
The incidence of PONV in Group G was lower than that in Group C (25.7% vs 57.1%, P < 0.01). The incidence of server nausea with vomiting or vomiting in Group G was lower than that in Group C (17.2% vs 48.6%, P < 0.01).
Granisetron can be used effectively and safely to prevent PONV in supratentorial craniotomy.
观察格拉司琼对幕上开颅术后恶心呕吐（PONV）的预防作用。
将70例择期行幕上开颅术的ASA I-II级患者随机双盲分为两组：对照组（C组，n = 35）和格拉司琼组（G组，n = 35）。所有患者分别静脉注射0.9%生理盐水（C组）或3 mg格拉司琼（G组）。记录幕上开颅术后24小时、48小时、72小时的术后恶心呕吐发生率。
G组PONV发生率低于C组（25.7%对57.1%，P < 0.01）。G组严重恶心伴呕吐或呕吐的发生率低于C组（17.2%对48.6%，P < 0.01）。
格拉司琼可有效、安全地用于预防幕上开颅术后的PONV。
