利用近红外扩散光和超声联合成像技术对肿瘤血管生成进行成像。
Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound.
作者信息
Zhu Quing, Chen NanGuang, Kurtzman Scott H
机构信息
Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269-2157, USA.
出版信息
Opt Lett. 2003 Mar 1;28(5):337-9. doi: 10.1364/ol.28.000337.
A novel two-step reconstruction scheme using a combined near-infrared and ultrasound technique and its utility in imaging distributions of optical absorption and hemoglobin concentration of breast lesions are demonstrated. In the first-step image reconstruction, the entire tissue volume is segmented based on initial coregistered ultrasound measurements into lesion and background regions. Reconstruction is performed by use of a finer grid for lesion region and a coarse grid for the background tissue. As a result, the total number of voxels with unknown absorption can be maintained on the same order of total measurements, and the matrix with unknown total absorption distribution is appropriately scaled for inversion. In the second step, image reconstruction is refined by optimization of lesion parameters measured from ultrasound images. It is shown that detailed distributions of wavelength-dependent absorption and hemoglobin concentration of breast carcinoma can be obtained with the new reconstruction scheme.
展示了一种使用近红外和超声组合技术的新型两步重建方案及其在乳腺病变光吸收和血红蛋白浓度成像分布中的应用。在第一步图像重建中，基于初始配准的超声测量将整个组织体积分割为病变区域和背景区域。通过对病变区域使用更精细的网格和对背景组织使用粗网格来进行重建。结果，具有未知吸收的体素总数可以保持在与总测量相同的数量级，并且具有未知总吸收分布的矩阵经过适当缩放以便求逆。在第二步中，通过优化从超声图像测量的病变参数来细化图像重建。结果表明，使用新的重建方案可以获得乳腺癌波长依赖性吸收和血红蛋白浓度的详细分布。
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