用于乳腺癌诊断和治疗监测的超声定位光学层析成像。
Optical tomography with ultrasound localization for breast cancer diagnosis and treatment monitoring.
作者信息
Zhu Quing, Tannenbaum Susan, Kurtzman Scott H
机构信息
Bioengineering Program, Electrical and Computer Engineering Department, 371 Fairfield Way, University of Connecticut, Storrs, CT 03269, USA.
出版信息
Surg Oncol Clin N Am. 2007 Apr;16(2):307-21. doi: 10.1016/j.soc.2007.03.008.
Abstract
Optical tomography with ultrasound (US) localization uses coregistered ultrasound images to guide optical imaging reconstruction. To simultaneously acquire US images and optical measurements, the authors used a hand-held probe consisting of a commercial US transducer and near-infrared optical imaging sensors of multiple wavelengths. A novel image scheme was used to map the ultrasound-visible lesions for optical imaging reconstruction. As a result, the problem of intense light scattering caused by breast tissue was overcome and reliable tumor hemoglobin concentration and blood oxygen saturation distributions from a group of patients were obtained. These functional parameters are valuable for aiding US diagnosis and for assessing chemotherapy response.
摘要
具有超声（US）定位功能的光学断层扫描利用配准的超声图像来指导光学成像重建。为了同时获取超声图像和光学测量数据，作者使用了一种手持探头，该探头由一个商用超声换能器和多个波长的近红外光学成像传感器组成。一种新颖的图像方案被用于绘制超声可见病变，以进行光学成像重建。结果，克服了乳腺组织引起的强光散射问题，并获得了一组患者可靠的肿瘤血红蛋白浓度和血氧饱和度分布。这些功能参数对于辅助超声诊断和评估化疗反应具有重要价值。
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