Honkoop P, Ouwendijk R J Th, Giard R W M, Bac D J
Ikazia Ziekenhuis, afd. Interne Geneeskunde, Montessoriweg 1, 3083 AN Rotterdam.
Ned Tijdschr Geneeskd. 2003 Feb 22;147(8):353-6.
Two female patients, aged 54 and 67 years, respectively, had suffered from watery diarrhoea for several weeks or months without cramps or blood in the stools. The findings upon physical examination, blood and faecal examination and endoscopy were normal, and subsequent histological examination of intestinal biopsies revealed collagenous colitis. After treatment with a high-fibre diet, sulphasalazine and either prednisone or budesonide, the symptoms subsided. Collagenous colitis is a chronic watery diarrhoea disorder with unknown aetiology and pathogenesis. It is characterised by macroscopically normal mucosa, while histopathologically an abnormal thickening of the subepithelial collagenous layer and an increase in the number of intra-epithelial lymphocytes is found. There are various treatment options such as dietary fibre, mesalazine or bismuthsubsalicylate. Recently budesonide has been found to have a favourable effect both clinically and histologically. Complications of the disease are rare.
两名女性患者，年龄分别为54岁和67岁，均患有水样腹泻数周或数月，无痉挛或便血症状。体格检查、血液及粪便检查以及内镜检查结果均正常，随后肠道活检的组织学检查显示为胶原性结肠炎。经高纤维饮食、柳氮磺胺吡啶以及泼尼松或布地奈德治疗后，症状缓解。胶原性结肠炎是一种病因和发病机制不明的慢性水样腹泻疾病。其特征为肉眼可见黏膜正常，而组织病理学表现为上皮下胶原层异常增厚以及上皮内淋巴细胞数量增加。有多种治疗选择，如膳食纤维、美沙拉嗪或碱式水杨酸铋。最近发现布地奈德在临床和组织学方面均有良好效果。该疾病的并发症罕见。
