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在基层医疗环境中对C反应蛋白即时检验进行现场测试和验证。

Field-testing and validation in a primary care setting of a point-of-care test for C-reactive protein.

作者信息

Seamark David A, Backhouse Susan N, Powell Roy

机构信息

Honiton Research Practice, Marlpits Lane, Honiton EX14 2NY, UK.

出版信息

Ann Clin Biochem. 2003 Mar;40(Pt 2):178-80. doi: 10.1258/000456303763046139.

DOI:10.1258/000456303763046139
PMID:12662408
Abstract

BACKGROUND

Use of point-of-care testing (POCT) in primary care has increased. There is a need for high-quality field evaluation of POCT before deployment can be considered.

METHOD

A POCT system for C-reactive protein was evaluated in a routine general practice setting. The standard laboratory method was a dry slide method based in a routine hospital laboratory.

RESULTS

Scatterplots for both venous and capillary blood POCT system results versus the standard laboratory assay produced correlation coefficients of greater than 0.96. Bland-Altman plots indicated that 95% of venous and capillary POCT results fell within +/-10 mg/L of the mean value with no clinically significant difference from laboratory results.

CONCLUSIONS

The POCT system performed reliably in a routine general practice setting with satisfactory performance against an accepted laboratory method.

摘要

背景

基层医疗中即时检验(POCT)的使用有所增加。在考虑推广之前,需要对POCT进行高质量的现场评估。

方法

在常规全科医疗环境中对一种C反应蛋白的POCT系统进行评估。标准实验室方法是基于常规医院实验室的干片法。

结果

静脉血和毛细血管血POCT系统结果与标准实验室检测的散点图产生的相关系数大于0.96。Bland-Altman图表明,95%的静脉血和毛细血管血POCT结果落在平均值的±10mg/L范围内,与实验室结果无临床显著差异。

结论

该POCT系统在常规全科医疗环境中表现可靠,与公认的实验室方法相比性能令人满意。

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