Taxis Katja, Barber Nick
Department of Practice and Policy, School of Pharmacy, University of London, London WC1 1AX.
BMJ. 2003 Mar 29;326(7391):684. doi: 10.1136/bmj.326.7391.684.
To determine the incidence and clinical importance of errors in the preparation and administration of intravenous drugs and the stages of the process in which errors occur.
Prospective ethnographic study using disguised observation.
Nurses who prepared and administered intravenous drugs.
10 wards in a teaching and non-teaching hospital in the United Kingdom.
Number, type, and clinical importance of errors.
249 errors were identified. At least one error occurred in 212 out of 430 intravenous drug doses (49%, 95% confidence interval 45% to 54%). Three doses (1%) had potentially severe errors, 126 (29%) potentially moderate errors, and 83 (19%) potentially minor errors. Most errors occurred when giving bolus doses or making up drugs that required multiple step preparation.
The rate of intravenous drug errors was high. Although most errors would cause only short term adverse effects, a few could have been serious. A combination of reducing the amount of preparation on the ward, training, and technology to administer slow bolus doses would probably have the greatest effect on error rates.
确定静脉用药配制和给药过程中差错的发生率、临床重要性以及差错发生的流程阶段。
采用隐蔽观察的前瞻性人种学研究。
配制和给予静脉用药的护士。
英国一家教学医院和一家非教学医院的10个病房。
差错的数量、类型及临床重要性。
共识别出249例差错。430剂静脉用药中,212剂(49%,95%置信区间45%至54%)至少发生了1例差错。3剂(1%)存在潜在严重差错,126剂(29%)存在潜在中度差错,83剂(19%)存在潜在轻度差错。大多数差错发生在给予大剂量推注药物或配制需要多步骤准备的药物时。
静脉用药差错发生率很高。虽然大多数差错只会引起短期不良反应,但少数可能很严重。减少病房内的配制量、培训以及采用缓慢推注给药技术相结合,可能对差错率产生最大影响。