Avakian R M, Dutov A A, Parkhomenko V M
Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(2):178-82.
The paper is concerned with a clinico-experimental study of the influence of intesified activity in the neostriatum on the EEG indices which may appear during the introduction of increased doses of corazol. In 10 cases with different forms of parkinsonism there was a much easier appearance of clinical and EEG manifestations of convulsive activity, than in normals. In experiments on rats preconvulsive effects were exerted by such neuroleptics as haloperidol unlike apomorphine, possessing opposite properties.
本文是关于新纹状体强化活动对在增加剂量的戊四氮引入过程中可能出现的脑电图指标影响的临床实验研究。在10例不同形式帕金森病患者中,惊厥活动的临床和脑电图表现比正常人更容易出现。在大鼠实验中,与具有相反特性的阿扑吗啡不同,氟哌啶醇等抗精神病药物具有惊厥前效应。