Rosenblum Michael D, Bredeson Christopher N, Chang Chung-Che, Rizzo J Douglas
Department of Medical Scientist Training Program (MSTP), Medical College of Wisconsin, Milwaukee, USA.
Am J Hematol. 2003 Apr;72(4):274-7. doi: 10.1002/ajh.10296.
We report the case of a 59-year-old woman with Durie-Salmon stage IIIB IgGkappa multiple myeloma (MM), who presented 83 days after autologous hematopoietic stem cell transplant (HSCT) with multiple subcutaneous plasmacytomas. These lesions were confined exclusively to sites where the patient had sustained local trauma. The patient had no pre-transplant history of extramedullary disease and no evidence of plasma cells in the peripheral blood at any time throughout the course of her disease. This case represents the first report of refractory MM presenting as multiple subcutaneous plasmacytomas with specific tropism to sites of previous trauma. Selection of tumor cell subclones with unique chemokine receptor expression profiles that may explain this clinical observation is discussed.
我们报告了一例59岁患有Durie-Salmon IIIB期IgGκ型多发性骨髓瘤（MM）的女性患者，她在自体造血干细胞移植（HSCT）后83天出现多处皮下浆细胞瘤。这些病变仅局限于患者曾遭受局部创伤的部位。该患者移植前无髓外疾病史，且在其病程中的任何时候外周血均无浆细胞证据。本病例是难治性MM表现为多处皮下浆细胞瘤且对既往创伤部位具有特异性嗜性的首例报告。文中讨论了选择具有独特趋化因子受体表达谱的肿瘤细胞亚克隆，这可能解释这一临床观察结果。
