Bruun J N, Solberg C O, Hamre E, Janssen C J, Thunold S, Eide J
Acta Pathol Microbiol Scand C. 1976 Apr;84(2):93-9. doi: 10.1111/j.1699-0463.1976.tb00004.x.
A 13-year-old girl with no previously known predisposing disease developed phycomycosis involving the left lung, pleura and shoulder, the left side of the neck, the left thigh, the kidneys and the brain. Prolonged amphotericin B therapy resulted in clinical improvement, but the disease was wide-spread when the patient died 5 months after debut of symptoms from a subarachnoid haemorrhage due to fungal destruction of the basilar artery. During hospitalization, a marked reduction in the bactericidal activity of circulating neutrophil granulocytes was repeatedly demonstrated and the endotoxin stimulated nitroblu tetrazolium test was negative. Together with the demonstration of granuloma formation and the accumulation of lipid-laden histiocytes in the spleen, lymph nodes, bone marrow and the thymus, these findings indicate that the patient had a less severe form of chronic granulomatous disease.
一名13岁女孩，既往无已知的易感疾病，却患上了藻菌病，累及左肺、胸膜和肩部、左侧颈部、左大腿、肾脏及脑部。长期使用两性霉素B治疗后临床症状有所改善，但在症状出现5个月后，患者因真菌破坏基底动脉导致蛛网膜下腔出血而死亡，此时疾病已广泛播散。住院期间，反复证明循环中性粒细胞的杀菌活性显著降低，内毒素刺激的硝基蓝四氮唑试验呈阴性。连同肉芽肿形成以及脾脏、淋巴结、骨髓和胸腺中充满脂质的组织细胞的积聚，这些发现表明该患者患的是一种不太严重的慢性肉芽肿病。
