Gurevich P S, Popov N P, Gurevich E P
Arkh Patol. 1975;37(8):13-9.
A pathomorphological investigation of 115 lethal cases of various forms of meningococcal infection was carried out. Meningococcemia, its instantaneous forms in particular, are characterized by acute decompensation of the lymphoid system and generalized microangiopathy with the thrombohaemorrhagic syndrome. Haemorrhagic necrosis of the adrenals and damage of the hypophysis represented manifestations of the acute decompensation of the hormonal regulation. Inflammatory changes in meningococcemia were observed not in all the cases (they were absent in 1/4 of the deceased). In meningitis (meningoencephalitis) without sepsis no generalized angiopathy was noted, immunomorphological changes were of a proliferative character. Previous sensibilization of the macroorganism was an important prerequisite for the development of meningococcal infection.
对115例各种形式的脑膜炎球菌感染致死病例进行了病理形态学研究。脑膜炎球菌血症，尤其是其瞬间发作形式，其特征为淋巴系统急性失代偿以及伴有血栓出血综合征的全身性微血管病。肾上腺出血性坏死和垂体损伤是激素调节急性失代偿的表现。并非所有脑膜炎球菌血症病例都观察到炎症变化（四分之一的死者无此变化）。在无败血症的脑膜炎（脑膜脑炎）中未发现全身性血管病，免疫形态学变化呈增生性。机体先前的致敏是脑膜炎球菌感染发生的重要前提。
