Gurevich P S, Barsukov V S
Arkh Patol. 1980;42(10):29-35.
Morphology of the lymphoid system was studied in 69 fatal cases due to sepsis, 25 due to massive local inflammatory processes and 18 sudden deaths (norm). In contrast to local inflammatory processes, the main feature of sepsis is a generalized reaction of the lymphoid system with signs of immunogenesis decompensation. Decompensation of the afferent part of immunogenesis manifested in glycogenolysis disorders, degenerative and necrotic changes of macrophages, inhibition of phagocytosis is important in the pathogenesis of sepsis. Decompensation of the central and efferent parts in most severe cases of sepsis is manifested in depletion of the lymph nodes and spleen and inhibition of immunoglobulin synthesis. The main issue in the pathogenesis of fulminating meningococcal sepsis is the formation of antigen-antibody immune complexes leading to the involvement of the microcirculatory channel vessels and disseminated intravascular blood coagulation.
对69例败血症致死病例、25例因局部严重炎症过程致死病例及18例猝死病例（正常对照）的淋巴系统形态学进行了研究。与局部炎症过程不同，败血症的主要特征是淋巴系统的全身性反应及免疫发生代偿失调迹象。免疫发生传入部分的代偿失调表现为糖原分解紊乱、巨噬细胞变性和坏死性改变、吞噬作用受抑制，这在败血症发病机制中很重要。在败血症最严重的病例中，中枢和传出部分的代偿失调表现为淋巴结和脾脏萎缩以及免疫球蛋白合成受抑制。暴发性脑膜炎球菌败血症发病机制的主要问题是抗原 - 抗体免疫复合物的形成，导致微循环通道血管受累及弥散性血管内凝血。
