[Pathogenesis of certain forms of sepsis].

Morphology of the lymphoid system was studied in 69 fatal cases due to sepsis, 25 due to massive local inflammatory processes and 18 sudden deaths (norm). In contrast to local inflammatory processes, the main feature of sepsis is a generalized reaction of the lymphoid system with signs of immunogenesis decompensation. Decompensation of the afferent part of immunogenesis manifested in glycogenolysis disorders, degenerative and necrotic changes of macrophages, inhibition of phagocytosis is important in the pathogenesis of sepsis. Decompensation of the central and efferent parts in most severe cases of sepsis is manifested in depletion of the lymph nodes and spleen and inhibition of immunoglobulin synthesis. The main issue in the pathogenesis of fulminating meningococcal sepsis is the formation of antigen-antibody immune complexes leading to the involvement of the microcirculatory channel vessels and disseminated intravascular blood coagulation.