Gurevich P S, Barsukov V S, Popov N P
Cor Vasa. 1983;25(6):443-9.
The analysis of post mortem examinations of 175 cases of meningococcal sepsis concentrates on a description of vascular changes as the chief manifestation of the given disease. The changes consisted in the destruction of the endothelium, mucoid swelling or fibrinoid changes of the wall of minute vessels, and disseminated intravascular blood clotting. In sum, these changes can be described as generalized microangiothrombopathy. In the affected vascular walls and in the thrombotic masses the presence of antigen-antibody immune complexes was found. It is therefore possible to regard hyperacute meningococcal sepsis as a manifestation of pathogenic action of immune complexes--as a consequence of massive blood invasion by antigen and of rapid formation of a great number of antigen-antibody complexes.
对175例脑膜炎球菌败血症尸检结果的分析着重描述了血管变化，这是该疾病的主要表现。这些变化包括内皮细胞破坏、微血管壁黏液样肿胀或纤维蛋白样改变以及弥散性血管内凝血。总之，这些变化可被描述为全身性微血管血栓形成病。在受影响的血管壁和血栓块中发现了抗原-抗体免疫复合物。因此，可以将超急性脑膜炎球菌败血症视为免疫复合物致病作用的一种表现——这是由于抗原大量侵入血液以及大量抗原-抗体复合物快速形成的结果。
