二价金属离子对人红细胞膜结合高亲和力钙离子敏感三磷酸腺苷酶的激活作用。
Activation of membrane-bound high-affinity calcium ion-sensitive adenosine triphosphatase of human erythrocytes by bivalent metal ions.
作者信息
Pfleger H, Wolf H U
出版信息
Biochem J. 1975 May;147(2):359-61. doi: 10.1042/bj1470359.
Abstract
The Ca2+-sensitive ATPase (adenosine triphosphatase) of human erythrocyte membranes is activated, not only by Ca2+ ions, but also by a series of other bivalent metal ions including Sr2+, Ba2+, Mn2+, Ni2+, Co2+, Cd2+, Cu2+, Zn2+ and Pb2+. The degree of activation is dependent on the radius of the ion rather than on its nature, in contrast with the dissociation constant of the enzyme--metal ion complex.
摘要
人红细胞膜上的钙离子敏感型三磷酸腺苷酶（ATP酶）不仅可被钙离子激活，还可被一系列其他二价金属离子激活，包括锶离子（Sr2+）、钡离子（Ba2+）、锰离子（Mn2+）、镍离子（Ni2+）、钴离子（Co2+）、镉离子（Cd2+）、铜离子（Cu2+）、锌离子（Zn2+）和铅离子（Pb2+）。与酶 - 金属离子复合物的解离常数相反，激活程度取决于离子半径而非其性质。
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