神经干细胞和祖细胞的分裂模式可能是皮质进化性扩张的基础。

Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion.

作者信息

Kriegstein Arnold, Noctor Stephen, Martínez-Cerdeño Verónica

机构信息

Institute for Stem Cell and Tissue Biology, University of California, San Francisco, 513 Parnassus Ave, HSW, 1201, San Francisco, California, USA.

出版信息

Nat Rev Neurosci. 2006 Nov;7(11):883-90. doi: 10.1038/nrn2008. Epub 2006 Oct 11.

DOI:10.1038/nrn2008

PMID:17033683

Abstract

The dramatic evolutionary expansion of the cerebral cortex of Homo sapiens underlies our unique higher cortical functions, and therefore bears on the ultimate issue of what makes us human. Recent insights into developmental events during early proliferative stages of cortical development indicate how neural stem and progenitor cells might interact to produce cortical expansion during development, and could shed light on evolutionary changes in cortical structure.

摘要

人类大脑皮层的显著进化扩张是我们独特的高级皮层功能的基础，因此关乎是什么造就了我们人类这一终极问题。最近对皮层发育早期增殖阶段发育事件的深入了解，揭示了神经干细胞和祖细胞在发育过程中可能如何相互作用以产生皮层扩张，并可能阐明皮层结构的进化变化。